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The binding of FITC-insulin to ANAE-positive cells in rat thymus

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To determine if thymic macrophages have insulin receptors, alternate sections of rat thymus were stained with FITC-insulin and examined for nonspecific esterase (ANAE) activity. Cells showing a diffuse ANAE staining pattern also bound FITC-insulin. These cells were concentrated in the cortico-medullary border and increased in number following administration of cortisol. Thymic macrophages may be insulin-dependent and therefore could be malfunctional in diabetes.

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Authors and Affiliations

  1. Department of Biochemistry, University of Nebraska College of Medicine, 68105, Omaha, Nebraska, USA

    J. F. Hofert, T. N. Mahowald, N. A. Mahowald & M. L. Heidrick

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  1. J. F. Hofert
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  2. T. N. Mahowald
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  3. N. A. Mahowald
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  4. M. L. Heidrick
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Hofert, J.F., Mahowald, T.N., Mahowald, N.A. et al. The binding of FITC-insulin to ANAE-positive cells in rat thymus. Experientia 44, 37–38 (1988). https://doi.org/10.1007/BF01960236

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  • DOI: https://doi.org/10.1007/BF01960236

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