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A pyruvate kinase variant in different mouse transplanted tumors

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Summary

Mouse transplanted tumors, in contrast to normal tissues, contain a pyruvate kinase (PK) variant sensitive to the inhibitory action of L-cysteine and less sensitive to saturated fatty acids than the normal enzyme. In selected normal and tumor materials two fractions of PK were separated. Fraction A (20–30% (NH4)2SO4 saturation) dominated in normal liver, and fraction B (50–60% (NH4)2SO4 saturation) in skeletal muscles and Ehrlich ascites tumor. Only this fraction B from tumor material was sensitive to L-cysteine, and seems to contain a tumor-specific PK variant which might be considered as a marker of neoplastic transformation in a broad spectrum of mouse experimental tumors.

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Authors and Affiliations

  1. Institute of Medical Biochemistry, Nicolaus Copernicus Academy of Medicine, Kopernika 7, 31-034, Cracow, Poland

    E. Marchut, M. Gumińska & T. Kędryna

  2. Hirszfeld Institute of Immunology and Experimental Therapy, Czerska 12, 53-114, Wroclaw, Poland

    Cz. Radzikowski & H. Kuśnierczyk

Authors
  1. E. Marchut
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  2. M. Gumińska
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  3. T. Kędryna
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  4. Cz. Radzikowski
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  5. H. Kuśnierczyk
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Marchut, E., Gumińska, M., Kędryna, T. et al. A pyruvate kinase variant in different mouse transplanted tumors. Experientia 44, 25–27 (1988). https://doi.org/10.1007/BF01960231

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