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The influence of different nutrients on plasma cholecystokinin levels in the rat

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Summary

Isocaloric and isovolemic amounts of protein (casein), fat (intralipid) and carbohydrate (saccharose) and an isovolemic control solution of water were administered intragastrically to conscious rats. The plasma CCK levels, determined by a sensitive and specific radioimmunoassay, showed an increment of 6.3±0.6, 2.7±0.5, 1.7±0.4 and −0.9±0.4 pM, respectively (basal value 2.5±0.3 pM). The threshold increment of plasma CCK to stimulate pancreatic enzyme secretion by exogenous CCK was found to be 1.5 pM. It is therefore concluded that casein is a potent stimulus for CCK secretion and pancreatic secretion, but that fat and even carbohydrate, although less potent, also produce a CCK increment above the threshold for pancreatic secretion.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, University Hospital Leiden, Bldg. 1 C4-P, P.O. Box 9600, NL-2300 RC, Leiden, The Netherlands

    B. R. Douglas, J. B. M. J. Jansen, A. J. L. de Jong & C. B. H. W. Lamers

  2. Department of Biological Toxicology, T.N.O.-CIVO Toxicology and Nutrition Institute, P.O. Box 360, NL-3700 AJ, Zeis, The Netherlands

    R. A. Woutersen

Authors
  1. B. R. Douglas
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  2. R. A. Woutersen
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  3. J. B. M. J. Jansen
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  4. A. J. L. de Jong
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  5. C. B. H. W. Lamers
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Additional information

Supported by Grant IKW 86-16 from the Netherlands Cancer Foundation KWF.

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Douglas, B.R., Woutersen, R.A., Jansen, J.B.M.J. et al. The influence of different nutrients on plasma cholecystokinin levels in the rat. Experientia 44, 21–23 (1988). https://doi.org/10.1007/BF01960229

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  • DOI: https://doi.org/10.1007/BF01960229

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