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Tetrodotoxin slightly shortens action potential duration in ventricular but not in atrial heart muscle

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Summary

Tetrodotoxin (TTX), at concentrations significantly decreasing maximal upstroke velocity (dV/dtmax) of the action potential, exerted variable effects on action potential duration (APD) in different myocardial preparations. APD was virtually unchanged by tetrodotoxin in the guinea pig atrium, but slightly shortened in the guinea pig ventricle at maximally effective concentrations. In the human ventricle, both dV/dtmax and APD were reduced in the same concentration range of TTX. These results suggest that a TTX-sensitive sodium current significantly contributes to the repolarization phase of the action potential in ventricular but not in atrial heart muscle.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Mainz, D-6500, Mainz, Germany

    H. Jakob & H. Nawrath

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  1. H. Jakob
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  2. H. Nawrath
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Supported by the Deutsche Forschungsgemeinschaft (Na 105/5-5) and by the Fonds der Chemischen Industrie. Author to whom reprint requests should be addressed. We thank Mrs. Johanna Rupp for expert technical help. We also thank one referee for suggesting the experiments depicted in figure 4.

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Jakob, H., Nawrath, H. Tetrodotoxin slightly shortens action potential duration in ventricular but not in atrial heart muscle. Experientia 44, 16–17 (1988). https://doi.org/10.1007/BF01960226

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