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A possible method for improving the efficacy of dapsone

Experientia volume 36, pages 1350–1351 (1980)Cite this article

Summary

The antileprosy drug dapsone is unable to penetrate intactMycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.

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Affiliations

  1. U.S. Public Health Service Hospital, 70721, Carville, LA, USA

    K. Prabhakaran, E.B. Harris & W.F. Kirchheimer

Authors
  1. K. Prabhakaran
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  2. E.B. Harris
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  3. W.F. Kirchheimer
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Prabhakaran, K., Harris, E. & Kirchheimer, W. A possible method for improving the efficacy of dapsone. Experientia 36, 1350–1351 (1980). https://doi.org/10.1007/BF01960091

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  • DOI: https://doi.org/10.1007/BF01960091

Keywords

  • Enzyme
  • Peptide
  • Sulfone
  • Cell Membrane
  • Bacillus