Abstract
Decomposition of vidarabine in a 5% glucose infusion fluid after steam sterilization was measured byhplc andtlc analysis. After sterilization for 60 minutes at 100°C and 20 minutes at 120°C no degradation could be observed. A slight but significant degradation was observed after sterilization for 60 minutes at 120°C followed by storage for eight months. Assuming 5% loss of content to be acceptable, it was concluded that a vidarabine infusion fluid can be sterilized for 20 minutes at 120°C and stored at room temperature for at least eight months afterwards.
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Stolk, L.M.L., Huisman, W., Nordemann, H.D. et al. Formulation of a stable vidarabine infusion fluid. Pharmaceutisch Weekblad Scientific Edition 5, 57–60 (1983). https://doi.org/10.1007/BF01960076
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DOI: https://doi.org/10.1007/BF01960076