Summary
The effect of pre- and postnatal lead exposure on the development of the serotonergic system in striatum and brain stem was investigated. Serotonin and its metabolite 5-HIAA where determined by HPLC-EC. A significant decrease of 5-HT was detected in the brain stem at postnatal day 28. At both days 6 and 28 postnatal, 5-HIAA was reduced in striatum and brain stem. The results provide support to the hypothesis that developing 5-HT neurons are sensitive to relatively low levels of lead exposure.
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Widmer, H.R., Bütikofer, E.E., Schlumpf, M. et al. Pre- and postnatal lead exposure affects the serotonergic system in the immature rat brain. Experientia 47, 463–466 (1991). https://doi.org/10.1007/BF01959945
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DOI: https://doi.org/10.1007/BF01959945