, Volume 47, Issue 5, pp 454–457 | Cite as

Age-related lipid peroxidation in the digestive gland of mussels: The role of the antioxidant defence systems

  • A. Viarengo
  • L. Canesi
  • M. Pertica
  • D. R. Livingstone
  • M. Orunesu
Research Articles


The main cellular defence systems against free radical-mediated oxidative stress are significantly reduced in the dige+ive gland of aged (>10 years old) compared to younger (2–4 years old) mussels (Mytilus edulis L.). Moreover, the concentration of lipid peroxidation products (malondialdehyde) is increased in the same age group with respect to younger animals. The obtained data indicate that an impairment of the antioxidant defence systems would render the older animals more susceptible to peroxidative stress, thus supporting the general significance of the free radical theory of aging.

Key words

aging mussels free radicals antioxidant systems lipid peroxidation 


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  1. 1.
    Hayflick, L., Exp. Geront.20 (1985) 145Google Scholar
  2. 2.
    Harman, D., Proc. natl Acad. Sci. USA78 (1981) 7124.Google Scholar
  3. 3.
    Reiss, U., and Gershon, D., Biochem. biophys. Res. Commun.73 (1976) 255.Google Scholar
  4. 4.
    Stege, T. E., Mischke, B. S., and Zipperer, W. C., Exp. Geront17 (1982) 273.Google Scholar
  5. 5.
    Videla, L. A., Fernandez, V., and Valenzuela, A., Cell Biochem. Funct.5 (1987) 273.Google Scholar
  6. 6.
    Rikans, L. E., and Moore, D. R., Biochem. biophys. Acta966 (1988) 269.Google Scholar
  7. 7.
    Bayne, B. L., Marine Mussels: Their Ecology and Physiology. Ed. B. L. Bayne. Cambridge University Press 1976.Google Scholar
  8. 8.
    Kappus, H., and Sies, H., Experientia37 (1981) 1233Google Scholar
  9. 9.
    Jones, D. P., in: Oxidative stress, p. 151. Ed. H. Sies. Academic Press. New York 1985.Google Scholar
  10. 10.
    Winston, G. W., Livingstone, D. R., and Lips, F., J. exp. Zool. (1990) in press.Google Scholar
  11. 11.
    Livingstone, D. R., Garcia Martinez, P., and Winston, G. W., Aquat. Toxic.15 (1989) 213.Google Scholar
  12. 12.
    Garcia Martinez, P., O'Hara, S., Winston, G. W., and Livingstone, D. R., Mar. Envir. Res. (1990) in press.Google Scholar
  13. 13.
    Bus, J. S., and Gibson, J. E., Rev. Biochem. Toxic. (1979) 125.Google Scholar
  14. 14.
    McCord, J. M., Rev. Biochem. Toxic. (1979) 109.Google Scholar
  15. 15.
    Ursini, F., and Bindoli, A., Analyt. Biochem.44 (1987) 255.Google Scholar
  16. 16.
    Hissin, P. J., and Hilf, R., Analyt. Biochem.74 (1976) 214.Google Scholar
  17. 17.
    Esterbauer, H., Lang, J., Zadravec, S., and Slater, T., Meth. Enzym.105 (1984) 319.Google Scholar
  18. 18.
    Viarengo, A., Canesi, L., Pertica, M., Poli, G., Moore, M. N., and Orunesu, M., Comp. Biochem. Physiol.97C (1990) 37.Google Scholar
  19. 19.
    Burton, k., Webb, A., and Ingold, K. V., Lipids20 (1985) 6049.Google Scholar
  20. 20.
    Campbell, S. A., Mar. Biol.4 (1969) 227.Google Scholar
  21. 21.
    Burton, K., Biochem. J.62 (1956) 315.Google Scholar
  22. 22.
    McCord, J. M., and Fridovich, I., J. biol. Chem.244 (1969) 6049.Google Scholar
  23. 23.
    Gunzler, W. A., and Flohé, L., in: Handbook Methods for Oxygen Radical Research, p. 285. Ed. R. A. Greenwald. CRC press, Boca Raton, Florida 1985.Google Scholar
  24. 24.
    Viarengo, A., Canesi, L., Pertica, M., and Orunesu, M., Atti Riunione congiunta SIBS, SIF, SINU, Taormina 1989.Google Scholar
  25. 25.
    Tollefsbol, T. O., and Cohen, H. J., Exp. Geront.21 (1986) 129.Google Scholar
  26. 26.
    Goldberg, E. D., Bowen, V. T., Farrington, J. W., Harvey, G., Martin, J. H., Parker, P. L., Risebrough, R. W., Robertson, W., Schneider, E., and Gamble, E., Envir. Conserv.5 (1978) 101.Google Scholar
  27. 27.
    Slater, T. F., Biochem. J.222 (1984) 1.Google Scholar

Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • A. Viarengo
    • 1
  • L. Canesi
    • 1
  • M. Pertica
    • 2
  • D. R. Livingstone
    • 1
  • M. Orunesu
    • 1
  1. 1.Istituto di Fisiologia GeneraleUniversità di GenovaGenovaItaly
  2. 2.Plymouth Marine LaboratoryPlymouthEngland

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