Summary
Mechanisms by which pancreatic secretions influence disaccharidase activities in the distal small intestine have been investigated in 1-week-old miniature pigs. Using a combination of biochemical, cytochemical and morphological techniques it has been found that the decrease in lactase specific activity is due solely to a reduction in villus surface area. By contrast, the increased sucrase-isomaltase activities, which occur despite the reduction in villus surface area, are due entirely to increased enzyme expression during enterocyte differentiation.
Similar content being viewed by others
References
James, P. S., Smith, M. W., Tivey, D. R., and Wilson, T. J. G., J. Physiol.393 (1987) 583.
Corring, T., Aumaitre, A., and Dorand, G., Nutr. Metab.22 (1978) 231.
Alpers, D. H., and Tedesco, F. J., Biochim. biophys. Acta401 (1975) 28.
Dowling, R. H., Scand. J. Gastroent. Suppl.7 (1982) 53.
James, P. S., Smith, M. W., and Tivey, D. R., J. Physiol.401 (1988) 533.
Goda, T., and Koldovsky, O., Biochem. J.29 (1985) 751.
Hauer-Jensen, M., Christensen, K., Wilson, M. D., and Schell, H. P., Pancreas2 (1987) 295.
Seethram, B., Perrillo, R., and Alpers, D. H., Gastroenterology79 (1980) 827.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tivey, D.R., Shulman, R.J. Effect of pancreatic secretions upon ileal disaccharidase activities of neonatal miniature pigs. Experientia 47, 452–454 (1991). https://doi.org/10.1007/BF01959941
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01959941