, Volume 37, Issue 4, pp 399–401 | Cite as

Quantitative changes in β-adrenergic responses of isolated atria from hyper- and hypothyroid rats

  • H. P. Rub
  • H. Thommen
  • H. Porzig


Concentration-response curves for the chronotropic and inotropic effects of isoprenaline, in the absence and presence of propranolol, were obtained on heart atria isolated from normo- or dysthyroid rats. Hyperthyroidism increased the chronotropic potency and efficacy of the β-adrenergic agonist. The results are compatible with the view that thyroid hormone increases the density of functional β-adrenoceptors in cardiac pacemaker tissue.


Propranolol Thyroid Hormone Hyperthyroidism Isoprenaline Quantitative Change 
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Copyright information

© Birkhäuser Verlag 1981

Authors and Affiliations

  • H. P. Rub
    • 1
  • H. Thommen
    • 1
  • H. Porzig
    • 1
  1. 1.Pharmakologisches Institut der UniversitätBern(Switzerland)

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