Summary
Although an unusually high incidence of a variety of infections in infants who had undergone splenectomy has been reported by a number of investigators the subject remains somewhat controversial. In the present experiments the role of the spleen in the protection of rats against experimentally induced hematogenous pyelonephritis was studied. The results of this study suggest that the spleen has an important preventive function against bacterial infection.
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References
R. Grofstein and S. S. Gellis, Am. J. Dis. Child.91, 566 (1956).
A. J. Eraklis and R. M. Filler, J. Pediat. Surg.7, 382 (1972).
H. King and M. G. Shumacker, Ann. Surg.136, 239 (1952).
W. H. Crosby and N. R. Benjamin, J. Path.39, 119 (1961).
E. F. Ellis and R. T. Smith, Pediatrics37, 111 (1966).
H. R. Shinefield, C. R. Steinberg and D. Kaye, J. exp. Med.123, 777 (1966).
V. V. Likhite, Nature253, 742 (1975).
H. Rothberg and L. A. Corallo, Proc. Soc. exp. Biol. Med.100, 220 (1959).
A. Öbek, Ö. Anĝ, İ. Petorak, A. İplikçi, E. Büget, L. Eroĝlu and M. Güngör, Chemotherapy19, 171 (1973).
A. Öbek, Z. Güvener, L. Eroĝlu, M. Güngör and M. Yurtkuran, Chemotherapy21, 67 (1975).
İ. Petorak, A. İplikçi, A. Öbek, Ö. Anĝ and E. Büget, Exp. Path.12, 174 (1976).
M. M. Zatz and E. M. Lance, J. exp. Med.134, 224 (1971).
N. R. St. C. Sinclair and E. V. Elliott, J. Immun.101, 251 (1968).
A. Constantopoulos, V. A. Najjar, S. B. Wish, T. H. Necheles and L. L. Stolbach, Am. J. Dis. Child125, 663 (1973).
J. R. Batisto, L. C. Cantor, F. Bosek, A. L. Goldstein and E. Canberra, Nature222, 1197 (1969).
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Güngör, M., Anĝ, Ö., İnanç, D. et al. The effect of splenectomy on the development of experimental pyelonephritis. Experientia 37, 387–389 (1981). https://doi.org/10.1007/BF01959878
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DOI: https://doi.org/10.1007/BF01959878