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Use of human somatotrophin in the treatment of a patient with methylmalonic aciduria

  • Metabolic Diseases
  • Original Paper
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Abstract

Growth hormone (GH) insufficiency was demonstrated in a patient with methylmalonic aciduria. GH administration at 14–21U/m2 per week accelerated linear growth, stimulated lipolysis, and produced clinical improvement and reduced urinary methylmalonate excretion. The clinical and metabolic benefits were lost as the dose of GH was increased to 28U/m2 per week.

Conclusion

The use of GH in other patients with methylmalonic aciduria (and other disorders of intermediary metabolism demonstrating similar clinical and metabolic features) warrants further study.

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Abbreviations

GH :

growth hormone

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Authors and Affiliations

  1. Paediatric Metabolism Unit, Department of Child Health, St George's Hospital Medical School, SW17 0RE, London, UK

    M. D. Bain, M. Jones & R. A. Chalmers

  2. Department of Medicine, St George's Hospital Medical School, SW17 0RE, London, UK

    S. S. Nussey

Authors
  1. M. D. Bain
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  2. S. S. Nussey
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  3. M. Jones
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  4. R. A. Chalmers
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Bain, M.D., Nussey, S.S., Jones, M. et al. Use of human somatotrophin in the treatment of a patient with methylmalonic aciduria. Eur J Pediatr 154, 850–852 (1995). https://doi.org/10.1007/BF01959796

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  • DOI: https://doi.org/10.1007/BF01959796

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