Skip to main content
Log in

No reduction in birth weight in phenylketonuria

  • Metabolic Diseases
  • Original Paper
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Birth weight in a total of 1886 British infants with phenylketonuria (PKU) born between 1964 and 1992 was examined in relation to sex, social class, gestational age, disease severity and birth year. Comparisons were made with two national surveys (British births 1970 and Office of Population Censuses and Surveys 1981). In contrast to a recent Dutch study, birth weight in British infants with PKU (mean 3307 g, median 3337g) showed a similar distribution to population norms. Birth weight showed no temporal trends and no trends with disease severity.

Conclusion

Birth weight is not reduced in British infants with PKU.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Abbreviations

Phe :

phenylalanine

PKU :

phenylketonuria

References

  1. Chamberlain R, Chamberlain G, Howlett B, Claireaux A (1975) British births 1970 Vol 1. William Heinemann Medical Books Ltd, London

    Google Scholar 

  2. Fisch RO, Feinberg SB, Weisberg S, Day D (1991) Bone changes of PKU neonates unrelated to phenylalanine levels. Am J Dis Child 14:890–895

    Google Scholar 

  3. Office of Population Censuses and Surveys (1983) Birthweight statistics 1981, 1982. OPCS Monitor

  4. Rothman KJ, Pueschel SN (1976) Birthweight in children with phenylketonuria. Pediatrics 1:809–813

    Google Scholar 

  5. Saugstad LF (1972) Birthweights in children with phenylketonuria and in their normal siblings. Lancet 58:842–844

    Google Scholar 

  6. Smith I, Carter CO, Wolff OH (1978) Birthweight of infants with phenylketonuria and their unaffected siblings. J Inherited Metab Dis 1:99–100

    Article  PubMed  Google Scholar 

  7. Smith I, Beasley MG, Ades AE (1990) Intelligence and quality of dietary treatment in phenylketonuria. Arch Dis Child 65:472–478

    PubMed  Google Scholar 

  8. Verkerk PH, Spronsen FJ van, Smit GPA, Cornel MC, Kuipers JRG, Verloove-Vanhorick SP (1991) Prevalence of congenital heart disease in patients with phenylketonuria. J Pediatr 119:282–283

    PubMed  Google Scholar 

  9. Verkerk PH, Spronsen FJ van, Smit GPA, Sengers RCA (1994) Impaired prenatal and postnatal growth in Dutch patients with phenylketonuria. Arch Dis Child 71:114–118

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tiliotson, S.L., Costello, P.M. & Smith, I. No reduction in birth weight in phenylketonuria. Eur J Pediatr 154, 847–849 (1995). https://doi.org/10.1007/BF01959795

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01959795

Key words

Navigation