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Soluble CD23 antigen in Kawasaki disease and other acute febrile illnesses

  • Infectious Diseases
  • Original Paper
  • Published:
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Abstract

Kawasaki disease (KD) is an acute febrile illness of early childhood. Although the epidemiology of KD suggests an infectious agent, the cause still remains unknown. Intense immune activation during the acute disease has been well documented. Quantitative determination of soluble CD23 in serum can serve as an index of macrophage/monocyte or B-cell activation. To further characterize the immunological profile in KD, we investigated whether soluble CD23 levels in serum increase during the acute disease. In addition, we compared soluble CD23 levels in 33 patients with acute KD with levels in ten patients each with measles, rubella, infectious mononucleosis, and scarlet fever to determine if marked elevations in soluble CD23 were unique to acute KD. Patients with KD, rubella and infectious mononucleosis, but not patients with measles or scarlet fever, had increased soluble CD23 levels in serum during the acute stage, as compared to age-matched control subjects (P<0.01). These data suggest infection with Epstein-Barr virus and rubella and acute KD are all characterized by B-cell and macrophage/monocyte activation.

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Abbreviations

CAL :

coronary-artery lesions

IM :

infectious mononucleosis

KD :

Kawasaki disease

MAb :

monoclonal antibodies

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Authors and Affiliations

  1. Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan

    Tomoyo Matsubara, Susumu Furukawa, Toshikazu Motohashi & Keijiro Yabuta

  2. Department of Paediatrics, Yamaguchi University School of Medicine, Yamaguchi, Japan

    Susumu Furukawa

  3. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Ko Okumura

  4. Department of Paediatrics 0609 D, University of California San Diego, School of Medicine, 92093-0609, La Jolla, CA, USA

    Tomoyo Matsubara

Authors
  1. Tomoyo Matsubara
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  2. Susumu Furukawa
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  3. Toshikazu Motohashi
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  4. Ko Okumura
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  5. Keijiro Yabuta
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Matsubara, T., Furukawa, S., Motohashi, T. et al. Soluble CD23 antigen in Kawasaki disease and other acute febrile illnesses. Eur J Pediatr 154, 826–829 (1995). https://doi.org/10.1007/BF01959791

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  • DOI: https://doi.org/10.1007/BF01959791

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