Pharmaceutisch Weekblad

, Volume 8, Issue 3, pp 194–197 | Cite as

Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at −20° C and thawing by microwave radiation

  • L. Keusters
  • L. M. L. Stolk
  • R. Umans
  • P. van Asten
Original Articles


Doxorubicin and epirubicin solutions in plastic minibags for intravesical use were stored at −20° C and thawed at room temperature or by microwave radiation. Concentrations were measured with HPLC and TLC. Doxorubicin and epirubicin solutions could be frozen and stored at −20° C during at least two and four weeks, respectively, and subsequently thawed without loss of content. When the thawed doxorubicin solutions were refrozen and thawed again five weeks later, only a slight decrease of content was measured.

Key words

Doxorubicin Epirubicin Freezing Quantitative analysis Stability Sterilization Thawing, microwave radiation 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • L. Keusters
    • 1
  • L. M. L. Stolk
    • 2
  • R. Umans
    • 3
  • P. van Asten
    • 1
    • 4
  1. 1.Department of Pharmacy, Division for Practical and Social PharmacyState University of UtrechtGH UtrechtThe Netherlands
  2. 2.Department of Pharmacy, Academic Medical CentreUniversity Hospital of AmsterdamAZ AmsterdamThe Netherlands
  3. 3.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamTV AmsterdamThe Netherlands
  4. 4.Department of PharmacyUniversity Hospital of UtrechtGV UtrechtThe Netherlands

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