Experientia

, Volume 38, Issue 10, pp 1239–1240 | Cite as

The germ cell — oncogenic and embryogenic correlates

  • B. Iyengar
Short Communications Genetics, Developmental Biology, Aging
  • 8 Downloads

Summary

This study is based on 100 consecutive germ cell tumors of the gonads, received during a 5-year period. Benign teratomas, with totipotent differentiation are the commonest ovarian germ cell tumors, whereas the nullipotent germinomas from the bulk of the testicular tumors. Differentiation in the rapidly proliferating testicular teratomas, occurs in the form of embryoid bodies and organoid structures. From an analysis of the germ cell tumors it is evident that the ovum confers differentiating functions on the zygote, while the spermatozoon confers functions of organization and proliferation. This difference in the behavior of the 2 germ cells is due to local feedbacks within the cortical and medullary zones of the gonads.

Keywords

Cell Tumor Germ Cell Teratoma Germ Cell Tumor Embryoid Body 

References

  1. 2.
    Witschi, E., Grady, H. G., and Smith, D. E., The ovary. Williams and Wilkins, Baltimore 1963.Google Scholar
  2. 3.
    Byskov, A. G., Annls Biol. anim. Biochim. Biophys.18, (1978) 327.Google Scholar
  3. 4.
    Moore, G. P. M., and Lintern Moores, S., J. Reprod. Fert.39 (1974) 163.Google Scholar
  4. 5.
    Bellair, R., Adv. Morphogen.4 (1964) 217.Google Scholar
  5. 6.
    Jahn, C. L., Baran, M. M., and Bachvarova, R., J. exp. Zool.197 (1976) 161.Google Scholar
  6. 7.
    Grootegoed, J. A., Peters, M. J., Moulder, E., Rommerts, F. F. G., and Molen Vander, M. J., Molec. Cell Endocr.9 (1977) 159.Google Scholar
  7. 8.
    Means, A. R., Fakunding, J. L., Huckins, C., Tindall, D. J., and Vitale, R., Rec. Prog. Horm. Res.32 (1976) 477.Google Scholar
  8. 9.
    Witschi, E., Experientia16 (1960) 274.Google Scholar
  9. 10.
    Short, R. V., Br. med. Bull.35 (1979) 121.Google Scholar
  10. 11.
    Woodruff, J. P., Protos, P., and Peterson, W. F., Am. J. Obstet. Gynec.102 (1968) 702.Google Scholar
  11. 12.
    Dixon, F. J., and Moore, R. A., Tumors of the male sex organs, p. 48. Armed Forces Inst. Path. Publ., 32. Washington, D.C. 1952.Google Scholar
  12. 13.
    Scully, R. E., Hum Path.1 (1970) 73.Google Scholar
  13. 14.
    Johnson, D. E., ed., Testicular tumors. Toppan Company (S) Pte Ltd, Singapore 1976.Google Scholar
  14. 15.
    Mostofi, F. K., and Sobin, L. H., Histological typing of testicular tumors. Int. Histological Classification of Tumors No. 16, WHO, Geneva 1976.Google Scholar
  15. 16.
    Pugh, R. C. B., and Smith, J. P., Br. J. Urol., suppl.36 (1964) 28.Google Scholar
  16. 17.
    Willis, R. A.: Teratoma. Armed Forces Inst. Path. Publ. Washington, D.C. 1951.Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • B. Iyengar
    • 1
  1. 1.Department of PathologyMaulana Azad Medical CollegeNew Delhi(India)

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