, Volume 38, Issue 10, pp 1224–1225 | Cite as

Multiple daily amphetamine administration decreases both [3H]agoinst and [3]antagonist dopamine receptor binding

  • D. R. Sibley
  • S. Weinberger
  • D. S. Segal
  • I. Creese
Short Communications Pharmacology, Toxicology


Multiple daily amphetamine injections in rats decreased both [3H]agonist as well as [3H]antagonist striatal dopamine receptor binding. Concurrently, these animals exhibited a decrease in striatal dopamine concentration and, paradoxically, an enhancement of behavioral responsivity.


Dopamine Amphetamine Receptor Binding Dopamine Receptor Striatal Dopamine 
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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • D. R. Sibley
    • 1
  • S. Weinberger
    • 1
  • D. S. Segal
    • 1
  • I. Creese
    • 1
  1. 1.Department of Neurosciences and Department of PsychiatryUniversity of CaliforniaLa JollaUSA

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