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Experientia

, Volume 38, Issue 10, pp 1224–1225 | Cite as

Multiple daily amphetamine administration decreases both [3H]agoinst and [3]antagonist dopamine receptor binding

  • D. R. Sibley
  • S. Weinberger
  • D. S. Segal
  • I. Creese
Short Communications Pharmacology, Toxicology

Summary

Multiple daily amphetamine injections in rats decreased both [3H]agonist as well as [3H]antagonist striatal dopamine receptor binding. Concurrently, these animals exhibited a decrease in striatal dopamine concentration and, paradoxically, an enhancement of behavioral responsivity.

Keywords

Dopamine Amphetamine Receptor Binding Dopamine Receptor Striatal Dopamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • D. R. Sibley
    • 1
  • S. Weinberger
    • 1
  • D. S. Segal
    • 1
  • I. Creese
    • 1
  1. 1.Department of Neurosciences and Department of PsychiatryUniversity of CaliforniaLa JollaUSA

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