Abstract
This is the last work to have been completed by Karl Ernst Schaefer, who died on December 26th 1981, in Old Lyme, Connecticut. The physiological changes and problems brought on by an excess of carbon dioxide was, for many years, one of the prime research interests of this eminent respiratory physiologist. In the present work, Schaefer explored the physiological limits of diving with varying N2−O2 mixtures. The paper contains a wealth of information relevant to the many still unanswered questions in the field and invaluable suggestions with respect to the course of future research. This work yielded, moreover, some interesting disease models for such disturbances as arrhythmia and bradycardia.
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Schaefer, K.E., Physiological stresses related to hypercapnia during patrols on submarines. Undersea Biomed. Res., Suppl.6 (1979) S15-S47.
Schaefer, K.E., Hastings, B.J., Carey, C.R., and Nichols, Jr, G., Respiratory acclimatization to carbon dioxide. J. appl. Physiol.18 (1963) 1071–1078.
Guillerm, R., and Radzisewski, E., Effects on many of 30-day exposure to PICO2=14 torr (2%): application to exposure limits. Undersea Biomed. Res., Suppl.6 (1979) S91-S114.
Schaefer, K.E., Respiration and acid-base balance during prolonged exposure to 3% CO2. Pflügers Arch.25 (1949) 689–694.
Clark, J.M., Sinclair, R.D., and Welch, B.E., Rate of acclimatization to chronic hypercapnia in man, in Underwater Physiology, pp. 399–408. Ed. C.J. Lambertsen. Academic Press, New York 1971.
Schaefer, K.E., Nichols, Jr. G., and Carey, C.R., Acid-base balance and blood using electrolytes of man during acclimatization to carbon dioxide. J. appl. Physiol.19 (1964) 48–58.
Polak, A., Haynie, G.D., Hayes, R.M., and Schwartz, W.B., Effect of chronic hypercapnia on electrolyte and acid-base equilibrium. I. Adaptation. J. clin. Invest.40 (1961) 1223–1237.
Schwartz, W.B., Brackett, Jr. N.C., and Cohen, J.J., The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiological limits of the defense of pH. J. clin. Invest.44 (1965) 291–301.
van Ypersele de Strihou, Brasseur, C.E.L., and DeConincok, J., The carbon dioxide response curve for chronic hypercapnia in man. N. Engl. J. Med.275 (1966) 117–125.
Schaefer, K.E., Nichols, G., and Carey, C.R., Calcium phosphorus metabolism in man during acclimatization to carbon dioxide. J. appl. Physiol.18 (1963) 1079–1084.
Messier, A.A., Heyder, E., Braithwaite, W.R. McCluggage, C., Peck, A., and Schaefer, K.E., Calcium, magnesium, and phosphorous metabolism and parathyroid-calcitonin function during prolonged exposure to elevated CO2 concentrations on submarines. Undersea Biomed. Res., Suppl.6 (1979) S57-S70.
Davies, D.M., Smith, D.J., Leitch, D.R., Morris, J.E.W., and Gray, S.P., The effects on man of continuous exposure to 0.5% carbon dioxide. Inst. nav. Med. Rep. 1976. No. 22/76. Alverstoke, England.
Davies, D.M., Sixty days in a submarine: the pathophysiological and metabolic cost. J. R. Coll. Physicians7 (1973) 132–144.
Poyart, C.F., Bursaux, E., and Freminet, A., The bone CO2 compartment: evidence for a bicarbonate pool. Resp. Physiol.25 (1975) 89–99.
Poyart, C.F., Freminet, A., and Bursaux, E., The exchange of bone CO2 in vivo. Resp. Physiol.25 (1975) 101–107.
Davies, D.M., and Morris, J.E.W., Carbon dioxide and vitamin D effects on calcium metabolism in nuclear submarines. Undersea Biomed. Res., Suppl.6 (1979) S71-S80.
Reichart, E., Caludon, F. and Sabliere, S., CO2 storage in various organs during chronic experimental hypercapnia. Bull. Eur. Physiopath. Resp.12 (1976) 19–32.
Brown, Jr, E.B., and Michel, C.C., Whole body CO2 exchange. Proc. XXIV Int. Congr. physiol. Sci.6 (1968) S185-S186.
Schaefer, K.E., Pasquale, S., Messier, A.A., and Shea, M., Phasic changes in bone CO2 fractions, calcium, and phosphorus during chronic hypercapnia. J. appl. Physiol; Resp. envir. Exercise Physiol.48 (1980) 802–811.
Pasquale, S., Messier, A.A., Shea, M.L., and Schaefer, K.E., Bone CO2 titration curves in acute hypercapnia. J. appl. Physiol, Resp. envir. Exercise Physiol.48 (1980) 197–200.
Tenney, S.M., and Naitove, A., Effects of alveolar oxygen and carbon dioxide on gastric secretion. Fedn. Proc.19 (1960) 190.
Blakemore, W.S., and Wolfson, S.K., Respiratory insufficiency as a factor in postoperative gastrointestinal bleeding. J. thorac. cardiovasc. Surg.44 (1962) 494–505.
Phil, B.G., Pohl, A.L., Dickens, R.A., and Glotzer, C.J., Effect of chronic hypercapnia on gastric secretion in the dog. Ann. Surg.165 (1967) 254–265.
Schaefer, K.E., Carey, C.R., Dougherty, J.H., Messier, A.A., and Morgan C., Effect of intermittent exposure to 3% CO2 on respiration, acid-base balance and calcium metabolism. Undersea Biomed. Res., Suppl.6 (1979) S115-S134.
Schaefer, K.E., Niemoeller, H., Messier, A.A., Heyder, E., and Spencer, J., Chronic CO2 toxicity: Species difference in physiological and histopathological effects. NAVSUB-MEDRSCHLAB Report 1971, No. 656.
Schaefer, K.E., Hasson, M., and Niemoeller, H., Effect of prolonged exposure to 15% CO2 on calcium and phosphorus metabolism. Proc. Soc. exp. Biol. Med.107 (1961) 355–359.
Schaefer, K.E., Avery, M.E., and Bensch, K., Time course of changes in surface tension and morphology of alveolar epithelial cells in CO2 induced hyaline membrane disease. J. clin. Invest.43 (1964) 2080–2093.
Schaefer, K.E., Pasquale, S.M., Messier, A.A., and Niemoeller, H., CO2 induced kidney calcification. Undersea Biomed. Res., Suppl.6 (1979) S143-S153.
Cohn, D.V., Bowden, R., and Eller, G.J., The effect of parthyroid hormone in vivo on the accumulation of calcium and phosphate by kidney and on kidney mitochondrial function. J. biol. Chem.242 (1967) 1253–1255.
Mahgoub, A., and Stern, P., Carbon dioxide and the effect of parathyroid hormone on bone in vitro. Am. J. Physiol.226 (1974) 1272–1275.
Crumb, Ch.K., Martinez-Muldonado, M., Eknoyan, G., and Suki, X., Effect of volume expansion, purified parathyroid extract and calcium on renal bicarbonate absorption in the dog. J. clin. Invest.54 (1974) 1287–1294.
Schaefer, K.E., Douglas, W.H.J., Messier, A.A., Shea, M.L., and Gohman, D.A., Effects of prolonged exposure to 0.5% CO2 on kidney calcification and ultra structure of lungs. Undersea Biomed. Res., Suppl.6 (1979) S155-S161.
Shea, M.L., Messier, A.A., and Bondi, K.R., Effect of prolonged exposure to low levels of CO2 concentration on kidney calcium and lung ultra structure. Fedn Proc.40 (1981) 675.
Douglas, W.H.J., Schaefer, K.E., Messier, A.A., and Pasquale, S.M., Proliferation of pneumocyte II cells in prolonged exposure to 1% CO2. Undersea Biomed. Res. Suppl.6 (1979) S135-S142.
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Schaefer, K.E. Effects of increased ambient CO2 levels on human and animal health. Experientia 38, 1163–1168 (1982). https://doi.org/10.1007/BF01959726
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DOI: https://doi.org/10.1007/BF01959726