European Journal of Pediatrics

, Volume 151, Issue 6, pp 455–457 | Cite as

Longitudinal assessment of infant lung function following pregnancies complicated by prolonged and preterm rupture of the membranes

  • P. Thompson
  • A. Greenough
  • K. H. Nicolaides


Serial measurements of functional residual capacity (FRC) were made in 22 infants (median gestational age at delivery 32 weeks, range 25–40) during the first 2 years of life. All infants had been delivered from pregnancies complicated by prolonged and preterm rupture of the membranes (PPROM) of at least 1 week in duration. The onset of membrane rupture was at a median of 26 weeks (range 15–32) with a median duration of 5.5 weeks (range 1–21). The mean FRC at all postnatal ages studied: 25 ml/kg at 6 and 12 months and 24ml/kg at 18 and 24 months did not differ significantly from the control population (mean 24ml/kg). There was, however, a wider scatter of results in the study population: four infants born very preterm consistently had FRC results above the 95% confidence limits of the controls but only two infants had FRCs consistently below this range. These results suggest PPROM may not be an invariable association of abnormal antenatal lung growth.

Key Words

Pulmonary hypoplasia Functional residual capacity Prematurity 



functional residual capacity


King's College Hospital


prolonged and premature rupture of the membranes


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • P. Thompson
    • 1
  • A. Greenough
    • 1
  • K. H. Nicolaides
    • 2
  1. 1.Department of Child HealthKing's College HospitalLondonUK
  2. 2.Department of ObstetricsKing's College HospitalLondonUK

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