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European Journal of Pediatrics

, Volume 151, Issue 6, pp 442–448 | Cite as

Epidemiology of vertically transmitted HIV-1 infection in Switzerland: Results of a nationwide prospective study

  • C. Kind
  • B. Brändle
  • C. -A. Wyler
  • A. Calame
  • C. Rudin
  • U. B. Schaad
  • J. Schüpbach
  • H. -P. Senn
  • L. Perrin
  • L. Matter
  • the Swiss Neonatal HIV Study Group
Infectious Diseases

Abstract

A nationwide study involving 286 children of human immunodeficiency virus (HIV)-infected mothers living in Switzerland has been performed with the participation of all paediatricians interested in HIV infection in the country. Of these children 201 could be followed up prospectively from birth up to a median age of 22 months. Prevalence of HIV infection in Swiss parturients was estimated at 0.1% and apparently remained stable from 1986 to 1989. Vertical transmission rate was estimated at 14%–20%. Variables of maternal or perinatal history were not associated with transmission rate. Transmission to pairs of siblings of the same mothers was discordant in 33% (6 of 18), with always the elder sibling being infected. Postneonatal mortality in infants of HIV-infected mothers followed up from birth was increased 15-fold over the general population with a very high incidence (2 in 100) of sudden infant death apparently unrelated to HIV infection.

Key words

HIV infections HIV seroprevalence Child Transmission Epidemiology 

Abbreviations

AIDS

acquired immune deficiency syndrome

CDC

centres for disease control

CI

confidence interval

HIV

human immunodeficiency virus

IVDU

intravenous drug use

OR

odds ratio

PCR

polymerase chain reaction

VC

virus culture

WB

western blot

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • C. Kind
    • 1
  • B. Brändle
    • 2
  • C. -A. Wyler
    • 3
  • A. Calame
    • 4
  • C. Rudin
    • 5
  • U. B. Schaad
    • 6
  • J. Schüpbach
    • 7
  • H. -P. Senn
    • 8
  • L. Perrin
    • 9
  • L. Matter
    • 10
  • the Swiss Neonatal HIV Study Group
    • 11
  1. 1.Division of NeonatologyKantonsspitalSt. GallenSwitzerland
  2. 2.Department of PaediatricsUniversity of ZürichSwitzerland
  3. 3.Department of PaediatricsUniversity of GenèveSwitzerland
  4. 4.Department of PaediatricsUniversity of LausanneSwitzerland
  5. 5.Department of PaediatricsUniversity of BaselSwitzerland
  6. 6.Department of PaediatricsUniversity of BernSwitzerland
  7. 7.Swiss National Centre for RetrovirusesZürichSwitzerland
  8. 8.Institute for Medical MicrobiologyUniversity of BaselSwitzerland
  9. 9.Laboratory for Viral SerologyUniversity of GenèveSwitzerland
  10. 10.Institute for Clinical Microbiology and ImmunologySt. GallenSwitzerland
  11. 11.Institute for Medical MicrobiologyUniversity of BernSwitzerland

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