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Epidemiology of vertically transmitted HIV-1 infection in Switzerland: Results of a nationwide prospective study

  • Infectious Diseases
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Abstract

A nationwide study involving 286 children of human immunodeficiency virus (HIV)-infected mothers living in Switzerland has been performed with the participation of all paediatricians interested in HIV infection in the country. Of these children 201 could be followed up prospectively from birth up to a median age of 22 months. Prevalence of HIV infection in Swiss parturients was estimated at 0.1% and apparently remained stable from 1986 to 1989. Vertical transmission rate was estimated at 14%–20%. Variables of maternal or perinatal history were not associated with transmission rate. Transmission to pairs of siblings of the same mothers was discordant in 33% (6 of 18), with always the elder sibling being infected. Postneonatal mortality in infants of HIV-infected mothers followed up from birth was increased 15-fold over the general population with a very high incidence (2 in 100) of sudden infant death apparently unrelated to HIV infection.

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Abbreviations

AIDS:

acquired immune deficiency syndrome

CDC:

centres for disease control

CI:

confidence interval

HIV:

human immunodeficiency virus

IVDU:

intravenous drug use

OR:

odds ratio

PCR:

polymerase chain reaction

VC:

virus culture

WB:

western blot

References

  1. Aiuti F, Luzi G, Mezzaroma I, Scano G, Papetti C (1989) Delayed appearance of HIV infection in children. Lancet II:858

    Google Scholar 

  2. Anonymous (1987) Centers for disease control classification system for human immunodeficiency virus (HIV) infection in children under 13 years of age. MMWR 36:225–236

    Google Scholar 

  3. Anonymous (1989) Association of state and territorial public health laboratory directors and AIDS program and centres for disease control. Interpretation and use of Western blot assay for serodiagnosis of human immunodeficiency virus type 1 infections. MMWR 38:1–7

  4. Blanche S, Rouzioux C, Guihard Moscato M-L, Veber F, Mayaux M-J, Jacomet C, et al (1989) A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. N Engl J Med 320:1643–1648

    Google Scholar 

  5. Böni J, Kind C, Jendis J, Schüpbach J (1991) Reliable diagnosis of pediatric HIV-infection within four months of life by combined use of polymerase chain reaction and virus culture [abstract]. Seventh international conference on AIDS, Istituto superiore di sanità: Rome, vol 1, p 46

    Google Scholar 

  6. Borkowsky W, Krasinski K, Paul D, Moore T, Bebenroth D, Chandwani S (1987) Human immunodeficiency virus infections in infants negative for anti-HIV by enzyme-linked immunoassay. Lancet I:1168–1171

    Google Scholar 

  7. Bundesamt für Gesundheitswesen (1991) Aidsfälle im Jahr 1990: Plateau erreicht? Bull BAG (3):28–32

    Google Scholar 

  8. Bundesamt für Statistik (1990) Statistisches Jahrbuch der Schweiz. Bundesamt für Statistik, Bern

    Google Scholar 

  9. Chavez CJ, Ostrea EM Jr, Stryker JC, Smialek Z (1979) Sudden infant death syndrome among infants of drug-dependent mothers. J Pediatr 95:407–409

    Google Scholar 

  10. Cox DR, Oakes D (1984) Analysis of survival data, Chapman and Hall, London

    Google Scholar 

  11. De Grandi P (1984) Expérience de dépistage sérologique de l'infection HIV chez les femmes enceintes. Schweiz Med Wochenschr 119:653–655

    Google Scholar 

  12. De Rossi A, Ades AE, Mammano F, DelMistro A, Amadori A, Giaquinto C, et al (1991) Antigen detection virus, culture, polymerase chain reaction, and in vitro antibody production in the diagnosis of vertically transmitted HIV-1 infection. AIDS 5:15–20

    Google Scholar 

  13. European Collaborative Study (1991) Children born to women with HIV-1 infection: natural history and risk of transmission. Lancet 337:253–260

    Google Scholar 

  14. Genesca J, Shih J W-K, Jett BW, Hewlett IK, Epstein JS, Alter HJ (1989) What do western blot indeterminate patterns for human immundeficiency virus mean in EIA-negative blood donors? Lancet II:1023–1025

    Google Scholar 

  15. Goedert JJ, Mendez H, Drummond JE, Robert-Guroff M, Minkoff HL, Holman S, et al (1989) Mother-to-infant transmission of human immunodeficiency virus type I: association with prematurity or low anti-gp 120. Lancet II:1351–1354

    Google Scholar 

  16. Guillod O, Kunz KL, Zenger CA (1991) Drei Gutachten über rechtliche Fragen im Zusammenhang mit AIDS. Abhandlungen zum schweizerischen Recht, Heft 529, Stämpfli, Bern

    Google Scholar 

  17. Henrion R, Henrion-Géant E, Mandelbrot L (1991) Infection à VIH chez la femme enceinte, résultats d'une enquête multicentrique en France métropolitaine. Bull Épidémiologique Hebdomadaire (6):21–23

    Google Scholar 

  18. Ho DD, Moudgil T, Alam M (1989) Quantitation of human immunodeficiency virus type 1 in the blood of infected persons. N Engl J Med 321:1621–1625

    Google Scholar 

  19. Hoff R, Berardi VP, Weiblen BJ, Mahoney-Trout BS, Mitchell ML, Grady GF (1988) Seroprevalence of human immunodeficiency virus among childbearing women. N Engl J Med 318:525–530

    Google Scholar 

  20. Irion O, Taban F (1988) SIDA en obstétrique et gynécologie. Mise sur pied d'une consultation. Bull Périnatologie Genève 3:1–5

    Google Scholar 

  21. Italian Multicentre Study (1988) Epidemiology, clinical features and prognostic factors of paediatric HIV infection. Lancet II:1043–1046

    Google Scholar 

  22. Johnson JP, Nair P, Hines SE, Seiden SW, Alger L, Revie DR, et al (1989) Natural history and serologic diagnosis of infants born to human immunodeficiency virus-infected women. Am J Dis Child 143:1147–1153

    Google Scholar 

  23. Kind C (1988) Epidemiologische Situation der prä- und perinatalen HIV-Infektion in der Schweiz (Zwischenbericht der neonatalen HIV-Studie) Schweiz Aerztezeitung 69:535–538

    Google Scholar 

  24. Künzel M, Kind C, Boppart C und Pädiatrische AIDS-Gruppe Schweiz (PAGS) (1991) Aufwachsen der Kinder HIV-positiver Mütter in der Schweiz [abstract]. Schweiz Med Wochenschr 121 [Suppl 41] S30

    Google Scholar 

  25. Oxtoby MJ (1990) Perinatally acquired human immunodeficiency virus infection. Pediatr Infect Dis J 9:609–619

    Google Scholar 

  26. Rogers MF, Ou C-Y, Rayfield M, Thomas PA, Schoenbaum EE, Abrams E, et al (1989) Use of the polymerase chain reaction for early detection the proviral sequences of human immunodeficiency virus in infants born to seropositive mothers. N Engl J Med 320:1649–1654

    Google Scholar 

  27. Rothman KJ (1986) Modern epidemiology, Little, Brown and Co, Boston Toronto

    Google Scholar 

  28. Rudin C, Senn HP, Berger R, Kühne T, Erb P (1991) Repeated polymerase chain reaction complementary to other conventional methods for early detection of HIV infection in infants born to HIV-infected mothers. Eur J Clin Microbiol Infect Dis 10:146–156

    Google Scholar 

  29. Ryder RW, Wato N, Hassig SE, Behets F, Rayfield M, Ekungola B, et al (1989) Perinatal transmission of the human immunodeficiency virus type 1 to infants of seropositive women in Zaire. N Engl J Med 320:1637–1642

    Google Scholar 

  30. Sanchez-Pescador R, Power MD, Barr PJ, et al (1985) Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2) Science 227:484–492

    Google Scholar 

  31. Scott GB, Fischl MA, Klimas N, Fletcher MA, Dickinson GM, Levine RS, et al (1985) Mothers of infants with the acquired immunodeficiency syndrome. JAMA 253:363–366

    Google Scholar 

  32. Stauber M, Schäfer A, Löwenthal D, Weingart B (1986) Das AIDS-Problem bei schwangeren Frauen — eine Herausforderung für den Geburtshelfer. Geburtshilfe Frauenheilkd 46:201–205

    Google Scholar 

  33. Yerli S, Chamot E, Déglon JJ, Hirschel B, Perrin LH (1991) Absence of chronic HIV infection without seroconversion in intravenous drug users. J Infect Dis 164:965–968

    Google Scholar 

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A complete list of all the participants in the study is available on request

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Kind, C., Brändle, B., Wyler, C.A. et al. Epidemiology of vertically transmitted HIV-1 infection in Switzerland: Results of a nationwide prospective study. Eur J Pediatr 151, 442–448 (1992). https://doi.org/10.1007/BF01959360

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  • DOI: https://doi.org/10.1007/BF01959360

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