Advertisement

Experientia

, Volume 40, Issue 1, pp 112–114 | Cite as

Acute changes in dopamine metabolism in the medio-basal hypothalamus following adrenalectomy

  • D. H. G. Versteeg
  • I. Van Zoest
  • E. R. De Kloet
Article

Summary

During the first hour following adrenalectomy the α-MPT-induced disappearance of dopamine was increased in the arcuate nucleus compared to that in sham-operated rats. In a number of other brain regions of both adrenalectomized and sham-adrenalectomized rats only stress-induced changes were observed in catecholamine utilization. These data suggest that corticosterone selectively modulates dopamine utilization in the medio-basal hypothalamus.

Keywords

Dopamine Brain Region Catecholamine Corticosterone Arcuate Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 3.
    De Kloet, E. R., Kovács, G. L., Szabó, G., Telegdy, G., Bohus, B., and Versteeg, D. H. G., Brain Res.239 (1982) 659.CrossRefPubMedGoogle Scholar
  2. 4.
    Bohus, B., and De Kloet, E. R., Life Sci.28 (1981) 433.CrossRefPubMedGoogle Scholar
  3. 5.
    Palkovits, M., Brain Res.59 (1973) 449.CrossRefPubMedGoogle Scholar
  4. 6.
    Fekete, M. I., Stark, E., Herman, J. P., Palkovits, M., and Kanyicska, B., Neurocsi. Lett.10 (1978) 153.CrossRefGoogle Scholar
  5. 7.
    Weiner, R. I., and Ganong, W. F., Physiol. Rev.58 (1978) 905.PubMedGoogle Scholar
  6. 8.
    Palkovits, M., Kobayashi, R. M., Kizer, J. S., Jacobowitz, D. M., and Kopin, I. J., Neuroendocrinology18 (1975) 144.PubMedGoogle Scholar
  7. 9.
    Fekete, M., Stark, E., Herman, J. P., and Palkovits, M., in: Cellular and Molecular Base of Neuroendocine Processes p. 601. Ed. E. Endröczi. Akademiai Kiado, Budapest 1975.Google Scholar
  8. 10.
    Kvetnansky, R., Palkovits, M., Mitro, A., Torda, T., and Mikulaj, Neuroendocrinology23 (1977) 257.PubMedGoogle Scholar
  9. 11.
    Kvetnansky, R., Kopin, I. J., and Saavedra, J. M., Brain Res.155 (1978) 387.CrossRefPubMedGoogle Scholar
  10. 12.
    Sauter, A. M., Baba, Y., Stone, E. A., and Goldstein, M., Brain Res.144 (1978) 415.CrossRefPubMedGoogle Scholar
  11. 13.
    Saavedra, J. M., Kvetnansky, R., and Kopin, I. J., Brain Res.160 (1979) 271.CrossRefPubMedGoogle Scholar
  12. 14.
    Stone, E. A., Freedman, L. S., and Morgano, L., Pharmac. Biochem. Behav.9 (1978) 551.CrossRefGoogle Scholar
  13. 15.
    Hedge, G. A., Van Ree, J. M., and Versteeg, D. H. G., Neuroendocrinology21 (1976) 236.PubMedGoogle Scholar
  14. 16.
    Thierry, A. M., Tassin, J. P., Blanc, G., and Glowinski, J., Nature263 (1976) 242.PubMedGoogle Scholar
  15. 17.
    Van der Gugten, J., Palkovists, M., Wijnen, H. J. L. M., and Versteeg, D. H. G., Brain Res.107 (1976) 171.CrossRefPubMedGoogle Scholar
  16. 18.
    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1984

Authors and Affiliations

  • D. H. G. Versteeg
    • 1
  • I. Van Zoest
    • 1
  • E. R. De Kloet
    • 1
  1. 1.Rudolf Magnus Institute for Pharmacology, Medical FacultyUniversity of UtrechtUtrecht(The Netherlands)

Personalised recommendations