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Experientia

, Volume 40, Issue 1, pp 65–67 | Cite as

Forskolin inhibits tension development in detergent-treated cardiac muscle fibers

  • G. Pfitzer
  • J. C. Rüegg
Short Communications

Summary

In detergent-treated cardiac muscle fibers, forskolin, a potent activator of adenylate cyclases, inhibits tension development elicited with submaximal [Ca2+] and increases incorporation of32P into troponin-I. A similar reduced tension development has been observed after treatment with cAMP or the catalytic subunit of the cAMP-dependent protein kinase. It is concluded that these fibers still contain much of the enzyme cascade involved in evoking a contractile response to \-adrenergic stimulation.

Keywords

Enzyme Protein Kinase Muscle Fiber Adenylate Cyclase Cardiac Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag Basel 1984

Authors and Affiliations

  • G. Pfitzer
    • 1
  • J. C. Rüegg
    • 1
  1. 1.Department of Physiology IIUniversity of HeidelbergHeidelberg(Federal Republic of Germany)

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