European Journal of Pediatrics

, Volume 151, Issue 10, pp 718–725 | Cite as

Epstein-Barr virus infection and associated diseases in children

I. Pathogenesis, epidemiology and clnical aspects
  • V. Schuster
  • H. W. Kreth
Review

Abstract

Epstein-Barr virus (EBV), an ubiquitous human B lymphotropic virus, is the cause of infectious mononucleosis. Moreover, EBV infection can be followed by lymphoproliferative diseases in patients with inherited and acquired immunodeficiencies. Primary EBV infection may be a threat to all children after marrow or organ transplantation or those receiving chronic immunosuppressive treatment for various other reasons. The virus has been also implicated in the pathogenesis of different malignant tumours such as Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin disease and some T-cell lymphomas. This review focuses on various aspects of virus-host interactions, immune mechanisms of the host, and the still experimental therapeutic approaches in EBV-associated diseases.

Key words

Epstein-Barr virus Lymphoproliferative syndromes Immunity Therapy 

Abbreviations

BL

Burkitt lymphoma

CFS

chronic fatigue syndrome

EA

carly antigen

EBNA

Epstein-Barr nuclear antigen

EBV

Epstein-Barr virus

IM

infectious mononucleosis

LMP

latent membrane protein

NPC

nasopharyngeal carcinoma

VAHS

virus-associated haemophagocytic syndrome

VCA

viral capsid antigen

XLP

X-linked lymphoproliferative syndrome

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • V. Schuster
    • 1
  • H. W. Kreth
    • 1
  1. 1.Department of PaediatricsUniversity of WürzburgWürzburgGermany

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