European Journal of Pediatrics

, Volume 151, Issue 10, pp 718–725 | Cite as

Epstein-Barr virus infection and associated diseases in children

I. Pathogenesis, epidemiology and clnical aspects
  • V. Schuster
  • H. W. Kreth


Epstein-Barr virus (EBV), an ubiquitous human B lymphotropic virus, is the cause of infectious mononucleosis. Moreover, EBV infection can be followed by lymphoproliferative diseases in patients with inherited and acquired immunodeficiencies. Primary EBV infection may be a threat to all children after marrow or organ transplantation or those receiving chronic immunosuppressive treatment for various other reasons. The virus has been also implicated in the pathogenesis of different malignant tumours such as Burkitt lymphoma, nasopharyngeal carcinoma, Hodgkin disease and some T-cell lymphomas. This review focuses on various aspects of virus-host interactions, immune mechanisms of the host, and the still experimental therapeutic approaches in EBV-associated diseases.

Key words

Epstein-Barr virus Lymphoproliferative syndromes Immunity Therapy 



Burkitt lymphoma


chronic fatigue syndrome


carly antigen


Epstein-Barr nuclear antigen


Epstein-Barr virus


infectious mononucleosis


latent membrane protein


nasopharyngeal carcinoma


virus-associated haemophagocytic syndrome


viral capsid antigen


X-linked lymphoproliferative syndrome


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • V. Schuster
    • 1
  • H. W. Kreth
    • 1
  1. 1.Department of PaediatricsUniversity of WürzburgWürzburgGermany

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