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The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat

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Summary

A marked increase of serum transaminase activities, histological changes of livers similar to those seen in viral hepatitis in man, and inhibition of hepatic protein synthesis were observed in rats following a single injection of D-galactosamine-HCl. These galactosamine-induced phenomena were prevented by the pretreatment of polyriboinosinic acidpolyribocytidylic acid 24 h before the galactosamine administration.

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Authors and Affiliations

  1. Department of Medical Chemistry, and First Department of Pathology, Osaka Medical College, Daigaku-cho 2-7, 569, Takatsuki City, Osaka, Japan

    S. Sakakibara, Y. Shibayama, I. Ueda & H. Kagamiyama

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  1. S. Sakakibara
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  2. Y. Shibayama
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  3. I. Ueda
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  4. H. Kagamiyama
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Additional information

This work was supported by a grant from Kanae Shinyaku Kenkyu-kai Fund. The technical assistance of Mr Yasuo Ueda is gratefully acknowledged.

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Sakakibara, S., Shibayama, Y., Ueda, I. et al. The protective effect of polyriboinosinic acid-polyribocytidylic acid against the occurrence of galactosamine-induced liver cell injury in rat. Experientia 39, 174–176 (1983). https://doi.org/10.1007/BF01958884

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