Experientia

, Volume 39, Issue 2, pp 164–165 | Cite as

Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats

  • J. Viña
  • F. J. Romero
  • G. T. Saez
  • F. V. Pallardó
Article

Summary

Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.

Keywords

Cell Membrane Glutathione Cysteine Intraperitoneal Injection Reduce Glutathione 

References

  1. 1.
    Viña, J., Hems, R., and Krebs, H.A., Biochem. J.170 (1978) 627.PubMedGoogle Scholar
  2. 2.
    Krebs, H.A., Hems, R., and Viña, J., in: Functions of glutathione in liver and kidney, p. 8. Eds. H. Sies and A. Wendel. Springer, Berlin, Heidelberg and New York 1978.Google Scholar
  3. 3.
    Viña, J., Romero, F.J., Estrela, J.M., and Viña, J.R., Biochem. Pharmac.29 (1980) 1968.CrossRefGoogle Scholar
  4. 4.
    Olney, J.W., and Ho, O.L., Nature, Lond.227 (1970) 609.Google Scholar
  5. 5.
    Olney, J.W., Ho, O.L., Rhee, V., and Schainker, B., Brain Res.45 (1972) 309.CrossRefPubMedGoogle Scholar
  6. 6.
    Mitchell, J.R., Thorgeirsson, S.S., Potter, W.Z., Jollow, D.J., and Keiser, H., Clin. Pharmac. Ther.16 (1974) 676.Google Scholar
  7. 7.
    Kossower, N.S., and Kossower, E.M., in Glutathione, p. 216. Eds L. Flohé, Ch. Benöhr, H. Sies, H.D. Waller and A. Wendel. Thieme, Stuttgart 1974.Google Scholar
  8. 8.
    Mitchell, J.R., Jollow, D.J., Potter, W.Z., Gillette, J.R., and Brodie, B.B., J. Pharmac. exp. Ther.187 (1973) 211.Google Scholar
  9. 9.
    Harrison, D.C., and Thurlow, S., Biochem. J.,20 (1926) 218.Google Scholar
  10. 10.
    Piperno, E., and Berssenbruegge, D.A., Lancet2 (1976) 738.CrossRefGoogle Scholar

Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • J. Viña
    • 1
  • F. J. Romero
    • 1
  • G. T. Saez
    • 1
  • F. V. Pallardó
    • 1
  1. 1.Dept. BioquímicaFacultad de MedicineValencia 10(Spain)

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