, Volume 39, Issue 2, pp 164–165 | Cite as

Effects of cysteine and N-acetyl cysteine on GSH content of brain of adult rats

  • J. Viña
  • F. J. Romero
  • G. T. Saez
  • F. V. Pallardó


Intraperitoneal injections of cysteine or N-acetyl cysteine induce a depletion of reduced glutathione (GSH) in rat brain. The doses required to promote GSH depletion are lower than those reported to cause a disseminate neurodegenerative syndrome. Since physiological GSH concentrations are required to maintain cell membranes, we suggest that consideration of the cysteine-induced GSH depletion is important in attempts to understand the mechanism of cysteine-induced cytotoxicity in brain.


Cell Membrane Glutathione Cysteine Intraperitoneal Injection Reduce Glutathione 
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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • J. Viña
    • 1
  • F. J. Romero
    • 1
  • G. T. Saez
    • 1
  • F. V. Pallardó
    • 1
  1. 1.Dept. BioquímicaFacultad de MedicineValencia 10(Spain)

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