Summary
Sodium fluoride (NaF) produced concentration-dependent relaxation of isolated rabbit ear artery precontracted with norepinephrine. In contrast, an arterial preparation with the endothelium rubbed off did not relax, but contracted in response to NaF. NaF-induced relaxation was not influenced by indomethacin but was inhibited by methylene blue or NG-monomethyl-L-arginine. The results indicate that NaF relaxes the artery by releasing a so-called EDRF.
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Tsuru, H. Endothelium-dependent relaxation induced by sodium fluoride in the rabbit ear artery. Experientia 47, 703–705 (1991). https://doi.org/10.1007/BF01958820
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DOI: https://doi.org/10.1007/BF01958820