European Journal of Pediatrics

, Volume 150, Issue 7, pp 507–508 | Cite as

Can high-dose immunoglobulin therapy be indicated in neonatal rhesus haemolysis?

A successful case of haemolytic disease due to rhesus (c+E) incompatibility
  • S. Kubo
  • T. Ariga
  • H. Tsuneta
  • T. Ishii


A male neonate with hyperbilirubinaemia and progressing anaemia due to rhesus (c+E) incompatibility received high dose intravenous gammaglobulin (ivIgG) therapy at 13 days of age. Clinical response to therapy was confirmed by a rapid decrease in serum bilirubin level, and with the prevention of a further decline of the haemoglobin level. No side-effects were noted. High dose ivIgG therapy could be an alternative to (exchange) blood transfusion in case of some haemolytic diseases of newborn.

Key words

High dose intravenous gammaglobulin therapy Haemolytic disease of newborn Rhesus incompatibility 



high-dose intravenous gammaglobulin


haemolytic disease of newborn




  1. 1.
    Berkman SA, Lee ML, Gale RP (1990) Clinical use of intravenous immunoglobulins. Ann Int Med 112:278–292PubMedGoogle Scholar
  2. 2.
    Berlin G, Selbing A, Ryden G (1985) Rhesus haemolytic disease treated with high-dose intravenous immunoglobulin. Lancet I:1153CrossRefGoogle Scholar
  3. 3.
    Camara CDL, Arrieta R, Gonzalez A, Iglesias E, Omenaka F (1988) High-dose intravenous immunoglobulin as the sole prenatal treatment for severe Rh immunization. N Engl J Med 318: 519–520PubMedGoogle Scholar
  4. 4.
    Derycke M, Dreyfus M, Ropert JC, Tchernia G (1985) Intravenous immunoglobulin for neonatal isoimmune thrombocytopenia. Arch Dis Child 60:667–669PubMedGoogle Scholar
  5. 5.
    Hara T, Mizuno Y, Kawano M, Ueki Y, Ueda K (1987) Treatment of immune hemolytic anemia with gammaglobulin. J Pediatr 110:817–818PubMedGoogle Scholar
  6. 6.
    Oda H, Honda A, Sugita K, Nakamura A, Nakajima H (1985) High-dose intravenous intact IgG infusion in refractory autoimmune hemolytic anemia (Evans syndrome). J Pediatr 107:744–746PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • S. Kubo
    • 1
  • T. Ariga
    • 1
  • H. Tsuneta
    • 1
  • T. Ishii
    • 1
  1. 1.Department of PaediatricsHokkaido Central Hospital for Social Health InsuranceSapporoJapan

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