Abstract
We report successful bone marrow transplantation (BMT) in two patients with severe combined immunodeficiency (SCID), who had developed BCG infection following neonatal vaccination. Patient 1 had Omenn Syndrome, associated with hypertrophic nonobstructive cardiomyopathy. Patient 2 had SCID due to adenosine deaminase deficiency. This communication demonstrates that with appropriate anti-mycobacterial cover, immunological reconstitution together with full recovery from BCG infection can be achieved by BMT. As demonstrated by persistant negative Mantoux tests, specific cell-mediated immunity to BCG was not acquired following BMT. We suggest that these children may continue to be at risk from mycobacterial infection.
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Abbreviations
- BMT:
-
bone marrow transplantation
- HCM:
-
hypertrophic nonobstructive cardiomyopathy
- SCID:
-
severe combined immunodeficiency
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Heyderman, R.S., Morgan, G., Levinsky, R.J. et al. Successful bone marrow transplantation and treatment of BCG infection in two patients with severe combined immunodeficiency. Eur J Pediatr 150, 477–480 (1991). https://doi.org/10.1007/BF01958426
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DOI: https://doi.org/10.1007/BF01958426