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Blood concentrations after accidental cyclosporin overdose

  • Pharmacology
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Abstract

Two cases of children are reported with an accidental oral overdose of cyclosporin in whom blood concentrations were monitored. Despite a tenfold oral overdose, the peak blood concentrations of cyclosporin in both patients were only moderately increased above therapeutic levels. Apart from a transient rise in blood pressure in one patient, no toxic effects of cyclosporia were noticed.

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Abbreviations

CNS:

central nervous system

References

  1. Baumhefner RW, Myers LW, Ellison GW, Tourtellote WW, Belendiuk GW, Wilkinson A, Levine B, Danovitch GM (1987) Huge cyclosporin overdose with favourable outcome. Lancet I:332

    Google Scholar 

  2. Burckart G, Starzl T, Williams L, Sanghvi A, Gartner C, Venkataraman R, Zitelli B, Malatack J, Urbach A, Diven W, Ptachcinski R, Shaw B, Iwatsuki S (1985) Cyclosporin monitoring and pharmacokinetics in pediatric liver transplant patients. Trans Proc 17:1172–1175

    Google Scholar 

  3. Cyclosporin package insert (1983) Sandoz, The Netherlands

  4. De Groen PC, Aksamait AJ, Rakela J, Forbes GS, Krom RAF (1987) Central nervous systems toxicity after liver transplantation. N Engl J Med 317:861–866

    PubMed  Google Scholar 

  5. Honcharik N, Anthone S (1985) Activated charcoal in acute cyclosporin overdose. Lancet I:1051

    Google Scholar 

  6. Niederberger W, Schaub P, Beveridge T (1980) High performance liquid chromatographic determination of cyclosporin A in human plasma and urine. J Chromatogr 182:454–458

    PubMed  Google Scholar 

  7. Ptachcinski RJ, Burckart GJ, Venkataraman R (1985) Cyclosporin. Drug Intell Clin Pharm 19:90–100

    PubMed  Google Scholar 

  8. Ptachcinski RJ, Venkataraman R, Burckart GJ (1986) Clinical pharmacokinetics of cyclosporin. Clin Pharmacokinet 11:107–132

    PubMed  Google Scholar 

  9. Schroeder TJ, Wadhwa NK, Pesce AJ, First MR (1986) An acute overdose of cyclosporin. Transplantation 41:406–409

    PubMed  Google Scholar 

  10. Wallemacq PE, Lesne ML (1985) Accidental massive IV administration of cyclosporin in man. Drug Intell Clin Pharm 19:29–30

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University Hospital Groningen, 59 Oostersingel, 9713 EZ, Groningen, The Netherlands

    K. de Meer, R. H. J. Houwen & C. M. A. Bijleveld

  2. Department of Pharmacy, University Hospital Groningen, 59 Oostersingel, 9713 EZ, Groningen, The Netherlands

    D. R. A. Uges

  3. Department of Surgery, University Hospital Groningen, 59 Oostersingel, 9713 EZ, Groningen, The Netherlands

    M. J. H. Slooff

Authors
  1. K. de Meer
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  2. R. H. J. Houwen
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  3. C. M. A. Bijleveld
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  4. D. R. A. Uges
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  5. M. J. H. Slooff
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de Meer, K., Houwen, R.H.J., Bijleveld, C.M.A. et al. Blood concentrations after accidental cyclosporin overdose. Eur J Pediatr 149, 219–220 (1989). https://doi.org/10.1007/BF01958287

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  • DOI: https://doi.org/10.1007/BF01958287

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