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Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations

  • Immunology/Allergology
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Abstract

We describe a 14-year-old girl with fatal infectious mononucleosis with high fever, pancytopenia, and multiple skin ulcers due toStaphylococcus aureus. Immunological studies revealed low serum IgM, low natural killer (NK) activity, and high CD4/CD8 ratio. Her father had also low NK activity and high CD4/CD8 ratio. It is suggested that she had a dominantly inherited immunodeficiency predisposing to severe Epstein-Barr virus infection.

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Abbreviations

EB:

Epstein-Barr

EBNA:

anti-EB nuclear antigen

IM:

infectious mononucleosis

NK:

natural killer

XLP syndrome:

X-linked lymphoproliferative syndrome

References

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Authors and Affiliations

  1. Division of Haematology/Oncology, Saitama Children's Medical Center, 2100 Magome Iwatsuki, 339, Saitama, Japan

    T. Inaba, R. Hanada, A. Yaginuma, Y. Hayashi & K. Yamamoto

  2. Division of Dermatology, Saitama Children's Medical Center, 2100 Magome Iwatsuki, 339, Saitama, Japan

    H. Hukada

Authors
  1. T. Inaba
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  2. R. Hanada
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  3. A. Yaginuma
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  4. Y. Hayashi
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  5. K. Yamamoto
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  6. H. Hukada
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Inaba, T., Hanada, R., Yaginuma, A. et al. Fatal infectious mononucleosis with staphylococcal pyoderma in a girl with hereditary immunological dysregulations. Eur J Pediatr 149, 177–178 (1989). https://doi.org/10.1007/BF01958275

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  • DOI: https://doi.org/10.1007/BF01958275

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