European Journal of Pediatrics

, Volume 149, Issue 3, pp 164–167 | Cite as

Serum IgG subclass concentrations in healthy subjects at different age: Age normal percentile charts

  • A. Plebani
  • A. G. Ugazio
  • M. A. Avanzini
  • P. Massimi
  • L. Zonta
  • V. Monafo
  • G. R. Burgio


IgG subclass levels were determined in 448 normal children from 6 months to 18 years of age and in 141 healthy adults by radial immunodiffusion using monoclonal antibodies. Age-normal percentile values were calculated for each year of age up to 18 years for IgG1, IgG2, IgG3 and in adults for all four subclasses. The broad spread of IgG4 values in children did not permit calculation of reference values.

Key Words

IgG subclasses Immunoglobulins 


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • A. Plebani
    • 1
  • A. G. Ugazio
    • 2
  • M. A. Avanzini
    • 1
  • P. Massimi
    • 1
  • L. Zonta
    • 3
  • V. Monafo
    • 1
  • G. R. Burgio
    • 1
  1. 1.Department of PaediatricsUniversity of PaviaPaviaItaly
  2. 2.Department of Paediatrics and BiotechnologyUniversity of BresciaItaly
  3. 3.Department of Genetics and MicrobiologyUniversity of PaviaItaly

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