, Volume 47, Issue 3, pp 261–263 | Cite as

Effects of the pyrimidine-containing cytochrome P-450 inhibitor, fenarimol, on the formation of 20-OH ecdysone in flies

  • P. Kulcsár
  • B. Darvas
  • H. Brandtner
  • J. Koolman
  • H. H. Rees
Research Articles


The effect of fenarimol, a pyrimidine-containing cytochrome P-450 inhibitor, was tested in vitro on brain-ring gland complexes ofCalliphora vicina (Dipt., Calliphoridae), and on microsomes prepared from the fat body of 0-h wandering stage larvae ofNeobellieria bullata (Dipt., Sacrophagidae). Fenarimol had no influence on the formation of ecdysone, but it was an effective inhibitor of cytochrome P-450-dependent ecdysone 20-monooxygenase.

Key words

Calliphora vicina Neobellieria bullata fenarimol synthesis of 20-hydroxy ecdysone cytochrome P-450 inhibitor microsomal ecdysone 20-monooxygenase 


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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • P. Kulcsár
    • 1
  • B. Darvas
    • 1
  • H. Brandtner
    • 2
  • J. Koolman
    • 2
  • H. H. Rees
    • 3
  1. 1.Department of Zoology, Plant Protection InstituteHungarian Academy of SciencesBudapest(Hungary)
  2. 2.Physiologisch-Chemisches Institut der Phillips-UniversitätMarburg(Germany)
  3. 3.Department of BiochemistryUniversity of LiverpoolLiverpool(England)

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