, Volume 47, Issue 3, pp 248–249 | Cite as

Inhibition of phosphoenolpyruvate carboxykinase by 6-phosphogluconate in rat liver

  • M. Kaloyianni
Research Articles


Various concentrations of 6-phosphogluconate inhibit rat liver phosphoenolpyruvate carboxykinase activity. 0.04 mM 6-phosphogluconate, which is the concentration found in vivo, caused a 50% inhibition of 6-phosphoenolpyruvate carboxykinase activity. 6-Phosphogluconate lowered the Vmax of the enzyme and increased the concentration of phosphoenolpyruvate required to achieve one-half of the maximum velocity. The role of 6-phosphogluconate as a regulator of the coordination of fluxes through three metabolic pathways is discussed.

Key words

Rat liver phosphoenolpyruvate carboxykinase 6-phosphogluconate 


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Copyright information

© Birkhäuser Verlag 1991

Authors and Affiliations

  • M. Kaloyianni
    • 1
  1. 1.Laboratory of Animal Physiology, Science SchoolAristotelian University of ThessalonikiThessaloniki(Greece)

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