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European Journal of Pediatrics

, Volume 155, Supplement 2, pp S21–S24 | Cite as

New modalities for treating neonatal infection

  • A. R. Bedford-Russell
Article

Abstract

While the overall incidence of infection has remained constant at approximately 7/1000 livebirths, the last decade has witnessed a reduction in early onset infections and a relative increase in nosocomial sepsis, chiefly with coagulase-negative staphylococci. Immaturity of host defence mechanisms contributes to an increasing susceptibility to infection with decreasing gestational age and birth weight. In the past, efforts to enhance host defence have included the use of granulocyte infusions, fresh frozen plasma, exchange blood transfusions and immunoglobulin therapy. Current trials are investigating the use of agents which enhance endogenous defence mechanisms, such as, recombinant human granulocyte colony-stimulating factant and recominant human granulocyte-macrophage colony-stimulating factor and of pentoxifylline. In the meantime strict attention to handwashing and aseptic technique remain the best methods of preventing nosocomial sepsis.

Key words

Neonatal infection Immunoglobulins rhG-CSF rhGM-CSF Pentoxifylline 

Abbreviations

VLBW

very low birth weight

IVIG

intravenous immunoglobulin

rhG-CSF

recombinant human granulocyte colony-stimulating factor

rhGM-CSF

recombinant human granulocyte-macrophage colony-stimulating factor

TNFα

tumour necrosis factor-alpha

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • A. R. Bedford-Russell
    • 1
  1. 1.Neonatal Intensive Care UnitSt George's HospitalLondonUK

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