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European Journal of Pediatrics

, Volume 151, Issue 11, pp 802–805 | Cite as

Chlorinated hydrocarbons in the bone Marrow of children: Studies on their association with leukaemia

  • J. Scheele
  • M. Teufel
  • K. H. Niessen
Hematology/Oncology

Abstract

Concentrations of chlorinated hydrocarbons and polyclorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean=3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.

Key words

Pesticides Chlorinated hydrocarbons Polychlorinated biphenyls Bone marrow Leukaemia 

Abbreviations

CHC

chlorinated hydrocarbons

DDE

dichlorodiphenyldichloroethylene

DDT

dichlorodiphenyltrichloroethane

HCB

hexachlorobenzene

HCH

hexachlorocyclohexane

PCB

polychlorinated biphenyls

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • J. Scheele
    • 1
  • M. Teufel
    • 1
  • K. H. Niessen
    • 1
  1. 1.Children's Hospital MannheimUniversity of HeidelbergMannheimGermany

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