Abstract
To asses the airway response to inhaled tobramycin we measured flow volume curves in 12 patients with cystic fibrosis. Immediately and/or 2 min after tobramycin inhalations there was a significant fall in lung function regardless of the concentration used; isotonic saline caused similar obstruction but not a complete cessation of peripheral air-flows. The baseline oxygen saturation was significantly correlated with the fall in lung function. Ten minutes after inhalation lung function tests returned to baseline values.
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Abbreviations
- CF :
-
cystic fibrosis
- FEV 1 :
-
forced expiratory volume in 1 s
- FVC :
-
forced vital capacity
- MEF 50 :
-
maximal expiratory flow at 50% of remaining forced vital capacity
- IsoMEF 50 :
-
maximal expiratory flow after inhalation measured at 50% of remaining forced vital capacity before inhalation
- TLC :
-
total lung capacity
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Nikolaizik, W.H., Jenni-Galović, V. & Schöni, M.H. Bronchial constriction after nebulized tobramycin preparations and saline in patients with cystic fibrosis. Eur J Pediatr 155, 608–611 (1996). https://doi.org/10.1007/BF01957914
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DOI: https://doi.org/10.1007/BF01957914