Abstract
A 15-year-old girl with common variable immunodeficiency contracted hepatitis C, which progressed to liver cirrhosis and finally to hepatic failure 5 years later. Since she was agammaglobulinaemic, hepatitis C virus (HCV) infection was diagnosed on the basis of HCV-RNA detection. Quantification of her sera showed high levels of HCV-RNA (more than 107 copies of RNA/mL), which implied active viral replication. There were no other hepatotoxic factors except HCV infection. The initial liver biopsy at 16 years of age and the autopsy confirmed a rapid progression in liver histopathological change over 4 years.
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Abbreviations
- HCV :
-
hepatitis C virus
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Sumazaki, R., Matsubara, T., Aoki, T. et al. Rapidly progressive hepatitis C in a patient with common variable immunodeficiency. Eur J Pediatr 155, 532–534 (1996). https://doi.org/10.1007/BF01957899
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DOI: https://doi.org/10.1007/BF01957899