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The subcellular distribution of lysergic acid diethylamide in the rat brain

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Résumé

Quinze min après une injection i.p. de LSD, près de 48% de la drogue présente dans le cerveau fut trouvée dans le surnageant, 20% dans la fraction nucléaire, 15% dans la fraction synaptosomale, 6% dans la fraction microsomale, 5% dans la fraction myélinique et près de 1,7% dans la fraction mitochondriale. Les fractions synaptosomale et mitochondriale sont presque saturées en LSD lors d'une injection de 10 mg/kg de LSD.

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Authors and Affiliations

  1. Biochemistry Laboratory, Division of Research, North Carolina Department of Mental Health, P. O. Box 7532, 27611, Raleigh, North Carolina, USA

    F. F. Faragalla

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  1. F. F. Faragalla
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Additional information

Acknowledgment. I thank Dr.J. Knopp for his help with the spectrophotoflourometric analysis.

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Faragalla, F.F. The subcellular distribution of lysergic acid diethylamide in the rat brain. Experientia 28, 1426–1427 (1972). https://doi.org/10.1007/BF01957828

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