Abstract
The kinetics of systemically and locally administered cefuroxime or ceftazidime in wound fluid were investigated in the period after vascular prosthetic implantation. Cefuroxime or ceftazidime was administered intravenously in patients. Simultaneously 250 mg ceftazidime or cefuroxime was added to preclotted blood. Locally administered antibiotics could not be detected in our samples. In groin fluid samples 24–48 h after the operation the average concentration of cefuroxime was 8.3 and of ceftazidime 5.0 mg/l. The decline of the concentration of cefuroxime or ceftazidime in groin fluid seems to be much slower than one would expect from the half-lives of the antibiotics. We conclude that cefuroxime and to a lesser extent ceftazidime are suitable as prophylactic agents in arterial reconstruction.
Similar content being viewed by others
References
Greco RS, Trooskin SZ, Donetz AP, Harvey RA. The application of antibiotic bonding to the treatment of established vascular prosthetic infection. Arch Surg 1985;120:71–5.
Sörensen TS, Aabech J, Utzon NP, Bruun B, Lorentzen JE. Kinetics of cefuroxime in the groin wound after vascular prosthetic implantation. J Vasc Surg 1988;8:143–6.
Rouan MC, Abadie F, Leclerq A, Juge P. Systemic approach to the determination of cephalosporins. J Chromatogr 1983;275:133–45.
Van Loenen AC, Roex AJMN, Willems HJJ, De Goede PNFC, Van Dijk A. Pharmacokinetics of cefoxitin in caesarean section. Ziekenhuisfarmacie 1987;3:47–51.
Greco RS, Harvey RA. The role of antibiotic bonding in the prevention of vascular prosthetic infections. Ann Surg 1982;195:168–71.
Foster JH, Berzins T, Scott HW. An experimental study of arterial replacement in the presence of bacterial infection. Surg Gynecol Obstet 1959;108:141–8.
De Neeling AJ, De Jong J, Landheer JE, et al. Onderzoek naar de resistentie tegen antibiotica in drie medische microbiologische laboratoria m.b.v. de microdilutie methode en geautomatiseerde dataverwerking. [Research into resistance against antibiotics in three medical microbiological laboratories with the microdilution method and computerized dataprocessing]. Bilthoven: Rijksinstituut voor Volksgezondheid en Milieuhygiëne, 1989.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Van Loenen, A.C., Martens, H.J.M., Mackaay, A.J.C. et al. Antibiotic concentrations in the groin wound after vascular prosthetic implantation. Pharmaceutisch Weekblad Scientific Edition 13, 179–181 (1991). https://doi.org/10.1007/BF01957743
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01957743