Pharmaceutisch Weekblad

, Volume 13, Issue 4, pp 161–166 | Cite as

The role of medicinal chemistry in drug research

  • W. Soudijn
Reviews

Abstract

Classical medicinal chemistry, that is molecular modifications of existing bioactive compounds, leading to me-too drugs with value added and often to me-too drugs which will never reach the market or to drugs in another pharmacological field than that originally intended, will be with us for a long time to come. The ultimate goal, however, is of course rational or at least semi-rational drug design. In some instances this goal seems to have already been reached as in the case of angiotensin-converting enzyme inhibitors and H2 antagonists. In the (near) future results from the steady progress in molecular biology in combination with computer-assisted drug modelling — possibly coupled with artificial intelligence techniques — will help the medicinal chemist in his efforts to attain this goal.

Keywords

Chemistry, pharmaceutical Computers Drug development Molecular biology Research 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • W. Soudijn
    • 1
  1. 1.Centre for Bio-Pharmaceutical Sciences, Division of Medicinal ChemistryLeiden UniversityRA LeidenThe Netherlands

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