Summary
Because of the presence of bombesin-like immunoreactivity in milk we investigated if enteral administration of bombesin affects the intestinal luminal content of trypsin and protein in 12-14-day-old rats. Bombesin (40 μg/kg), given either orogastrically or subcutaneously, produced a significant elevation in the intestinal content of trypsin activity. Thus, enterally-administered bombesin can produce acute biologic effects in suckling rats.
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Erspamer, V., Falconieri Erspamer, G., Inselvini, M., and Negri, L., Br. J. Pharmac.45 (1972) 333.
Walsh, J. H., Reeve, J. R. Jr, and Vigna, S. R., in: Gut Hormones, p. 413. Eds S. R. Bloom and J. M. Polak. Churchill Livingston, New York 1981.
Namba, M., Ghatei, M. A., Ghiglione, M., and Bloom, S.R., Digestion34 (1986) 105.
Deschodt-Lanckman, M., Roberrecht, P., De Neef, P., Lammens, M., and Christophe, J., J clin. Invest.58 (1976) 891.
Jensen, R. T., Moody, T., Pert, C., Rivier, J. E., and Gardner, J. D., Proc. natl Acad. Sci. USA75 (1978) 6139.
Jahnke, G. D., and Lazarus, L. H., Proc. natl Acad. Sci. USA81 (1984) 578.
Ekman, R., Ivarsson, S., and Jansson, L., Reg. Pept.10 (1985) 99.
Westrom, B. R., Ekman, R., Svendsen, L., Svendsen, J., and Karlsson, B. W. J. Pediatr. Gastroent. Nutr.6 (1987) 460.
Lazarus, L. H., Gaudino, G., Wilson, W. E., and Erspamer, V., Experientia42 (1986) 822.
Koldovský, O., Bedrick, A., Pollack, P. F., Rao, R. K., and Thornburg, W. T., in: Biology of Human Milk, p. 123. Ed. L. A. Hanson. Raven Press, New York 1988.
Pollack, F., Adamson, C., and Koldovský, O., Pediatr. Res.23 (1988) 250A.
Hahn, P., and Koldovský, O., in: Utilization of Nutrients During Postnatal Development, p. 1–15. Pergamon Press, 1967.
Pollack, P. F., Pancreas, in press.
Johnson, L. R., and Guthrie, P. D., Am. J. Physiol.245 (1983) G725.
Lowry, D. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem.193 (1951) 265.
Erlanger, B. F., Kokowsky, N., and Cohen, W., Archs. Biochem. Biophys.95 (1961) 271.
Bruning, J. L., and Kintz, B. L., Computational Handbook of Statistics. Scott, Foresman, and Co., Glenview, Illinois, 1977.
Koldovský, O., and Thornburg, W., J. Pediatr. Gastroent. Nutr.6 (1988) 172.
O'Loughlin, E. V., Chung, M., Hollenberg, M., Hayden J., Zahavi, I., and Gall, D. G., Am. J. Physiol.249 (1985) G674.
Lehy, T., Influence of bombesin on GI cell growth. Presented at the First International Symposium on Bombesin and Bombesin-Related Peptides in Health and Disease, Rome, Italy, October 13–16, 1987.
Erspamer, V., in: Gastrointesinal Hormones, p. 343. Ed. G. B. J. Glass. Raven Press, New York 1980.
Kai, H., Tajiri, H., Lee, P. C., and Lebenthal, E., J. Pediatr. Gastroent. Nutr.3 (1984) 328.
Megel, H., Strauss, R., Ho, R., and Beiler, M., Archs. Biochem. Biophys.108 (1964) 193.
Udall J. N., Bloch, K. J., Newman, A. P., Dixon, M., and Walker, W. A., Am. J. Physiol.247 (1984) G183.
Green, G. M. and Nasset, E. S., Gastroenterology79 (1980) 695.
Kortz, W. J., Nashold, J. R. B., DeLong, E., and Meyers, W. C., Ann. Surg.203 (1986) 1.
Kaminski, D. L., and Deshpande, Y. G., Gastroenterology85 (1983). 1239.
Knodell, R. G., Steele, N. M., and Stanley, L. N., Dig. Dis. Sci.32 (1987) 1290.
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Pollack, P.F., Adamson, C. & Koldovsky, O. Effects of enterally- and parenterally-administered bombesin on intestinal luminal tryptic activity and protein in the suckling rat. Experientia 45, 385–388 (1989). https://doi.org/10.1007/BF01957488
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DOI: https://doi.org/10.1007/BF01957488