Abstract
In an extremely low birth weight infant fed expressed own mother's milk exclusively during the first 6 months of life, introduction of a human milk fortifier resulted in improvement of biochemical alterations consistent with metabolic bone disease of prematurity. Attempts to discontinue fortification at 9 weeks (discharge) and 21 weeks of age induced deterioration of biochemical parameters, demonstrating a persistent need for mineral supplementation during the whole period of breastfeeding. The effects of long-term human milk fortification are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- ELBW:
-
extremely low birth weight
- HM:
-
human milk
- HMF:
-
human milk fortification
- LGA:
-
light for gestational age
- OMM:
-
Own mother's milk
References
Abrams SA, Schanler RJ, Garza C (1988) Bone mineralisation in former very low birth weight infants fed either human milk or commercial formula. J Pediatr 112:956–960
Greer FR, McCormick A (1988) Improved bone mineralisation and growth in premature infants fed fortified own mother's milk. J Pediatr 112:961–969
Hall RT, Wheeler RE, Montalto MB, Benson JD (1989) Hypophosphatemia in breast-fed low-birth-weight infants following initial hospital discharge. Am J Dis Child 143:1191–1195
Koo WWK, Gupta JM, Nayanar VV, Wilkinson M, Posen S (1982) Skeletal changes in preterm infants. Arch Dis Child 57: 447–452
Lyon AJ, McIntosh N (1984) Calcium and phosphorus balance in extremely low birthweight infants in the first six weeks of life. Arch Dis Child 59:1145–1150
Modanlou HD, Lim MO, Hansen JW, Sickles V (1986) Growth, biochemical status, and mineral metabolism in very low birthweight infants receiving fortified preterm human milk. J Pediatr Gastroenterol Nutr 5:762–767
Petersen S, Gotfredsen A, Knudsen FU (1989) Total body bone mineral in light-for-gestational-age infants and appropriate-for-gestational-age infants. Acta Paediatr Scand 78:347–350
Raupp P, Kries R v, Schmidt E, Manz F, Tönz O (1988) Human milk fortification. Lancet I:1160–1161
Reade TM, Scriver CR (1979) Hypophosphatemic rickets and breast milk. N Engl J Med 300:293
Rowe J, Rowe D, Horak E, Spackman T, Saltzman R, Robinson S, Philipps A, Raye J (1984) Hypophosphatemia and hypercalciuria in small premature infants fed human milk: evidence for inadequate dietary phosphorus. J Pediatr 104:112–117
Schanler RJ, Garza C (1988) Improved mineral balance in very low birth weight infants fed fortified human milk. J Pediatr 112:452–456
Steichen JJ, Krug-Wispé SK, Tsang RC (1987) Breastfeeding the low birth weight preterm infant. Clin Perinatol 14:131–171
Tönz O, Schubiger G (1985) Feeding of very-low-birth-weight infants with breast-milk enriched by energy, nitrogen and minerals: FM 85. Helv Paediatr Acta 40:235–247
Ylppö A (1919) Zur Physiologie, Klinik und zum Schicksal der Frühgeborenen. Das Wachstum der Frühgeborenen von der Geburt bis zum Schulalter. Z Kinderheilkd 24:96—110/167—178
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raupp, P., v. Kries, R., Schmiedlau, D. et al. Biochemical evidence for the need of long-term mineral supplementation in an extremely low birth weight infant fed own mother's milk exclusively during the first 6 months of life. Eur J Pediatr 149, 806–808 (1990). https://doi.org/10.1007/BF01957288
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01957288