Abstract
Serum levels of calcium (Ca), calcitonin (CT) and parathyroid hormone (PTH) were determined in cord blood of 229 newborns. In 136 newborns the tests were repeated 24h later. The probands were divided into four groups according to mode of delivery: (1) spontaneous; (2) elective caesarean section without labour; (3) elective caesarean section in labour; (4) emergency caesarean section with fetal distress. Newborns in group 2 had significantly lower Ca and CT levels and significantly higher PTH concentrations in cord blood than the other three groups. In all groups Ca and PTH concentrations were negatively correlated. At 24 h, mean Ca levels had decreased and mean CT and PTH concentrations had increased in all four groups. Newborns in group 2 still had lower Ca levels but higher CT and PTH concentrations. At that time there were negative correlations between Ca and CT levels in groups 1 and 2 and between Ca and PTH concentrations in group 1. These data demonstrate that without labour, cord blood Ca and CT levels are lower and PTH concentrations are higher. The low 24h calcium in newborns delivered without labour is explained by the lower Ca levels at birth and a tremendous increase of CT. The PTH secretion in full-term newborns is very substantial and negatively correlated with Ca levels.
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Abbreviations
- Ca:
-
calcium
- CT:
-
calcitonin
- ECS:
-
elective caesarean section without labour
- ECSL:
-
elective caesarean section in labour
- EMCS:
-
emergency caesarean section for fetal distress
- PTH:
-
parathyroid hormone
- RIA:
-
radioimmunoassay
- SD:
-
spontaneous delivery
References
Bagnoli F, De Leo V, Bruchi S, Buonocore G, Berni S, Talluri B, Bracci R (1984) Calcitonin, parathyroid hormone and prolactin concentrations in the first days of life in relation to the mode of delivery. In: Jaffe RB, Dell'Acqua S (ed) The endocrine physiology of pregnancy and peripartal period. Serono Symposia, 11–13 April, Rome, p 16
Bagnoli F, Bruchi, S, Pecciarini L, Monti E, Garosi G, Fabbo A, Vispi L (1986) Possibile influenza del paratormone sul mecanismo del travaglio di parto. Boll Soc Ital Biol Sper 62:459–463
Bagnoli F, Bruchi S, Vispi L, Martorana E, Inaudi P, Monti E (1986) ACTH, cortisol and progesterone secretion in newborn infants delivered by vaginal delivery and caesarean section. In: Jährig K, Woraschk HJ, Röpke F (eds) 10th European Congress of Perinatal Medicine, 12–16 August, Halle, p 325
Bagnoli F, Bruchi S, Garosi G (1987) Metabolismo calcio-fosforico nella madre e nel neonato in relazione alla modalità del parto. In: Genazzani AR, Volpe A, Facchinetti F (eds) Ostetricia e Ginecologia '87. CIC Edizioni Internazionali. Rome, pp 189–196
Bowers SK, MacDonald HM, Shapiro ED (1982) Prevention of iatrogenic neonatal respiratory distress syndrome: elective repeat cesarean section and spontaneous labor. Am J Obstet Gynecol 143:186–189
Crawford, JS, James FM III, Davies, P, Crawley, M (1976) A further study of general anaesthesia for caesarean section. Br J Anaesth 48: 661–667
Facchinetti F, Bagnoli F, Sardelli S, Petraglia F, De Leo V, Bracci R, Genazzani AR (1986) Plasma opioids in the newborn in relation to the mode of delivery. Gynecol Obstet Invest 21:6–11
Gittleman IF, Pincus JB (1951) Influence of diet on the occurrence of hyperphosphatemia and hypocalcemia in the newborn infant. Pediatrics 8:778–787
Jacobstein MD, Hirschfeld SS, Flinn C, Riggs T, Fanaroff A (1982) Neonatal circulatory changes following elective cesarean section: an echocardiographic study. Pediatrics 69:364–376
Kruse K, Kustermann W (1987) Evidence for transient peripheral resistance to parathyroid hormone in premature infants. Acta Paediatr Scand 76:115–118
Leclaire M, Gamerre M, Unal D, Martin A (1979) Conséquences néo-natales da la césarienne sur enfant présumé sain. Ann Anesth Fr 8:691–696
Pang PKT, Shew RL, Sawyer WH (1981) Inhibition of uterine contraction by synthetic parathyroid hormone fragment. Life Sci 28:1317–1321
Swanström S, Bratteby LE (1981) Metabolic effects of obstetric regional analgesia and of asphyxia in the newborn infant during the first two hours after birth. Acta Paediatr Scand 70:791–800
Thomas ML, Anast CS, Forte LR (1981) Regulation of calcium homeostasis in the fetal and neonatal rat. Am J Physiol 240:E367-E372
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Bagnoli, F., Bruchi, S., Garosi, G. et al. Relationship between mode of delivery and neonatal calcium homeostasis. Eur J Pediatr 149, 800–803 (1990). https://doi.org/10.1007/BF01957286
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DOI: https://doi.org/10.1007/BF01957286