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European Journal of Pediatrics

, Volume 149, Issue 11, pp 762–764 | Cite as

Isolated dehydroepiandrosterone sulphate hypersecretion: A case report

  • G. Radetti
  • E. Cacciari
  • M. Zachmann
Endocrinology

Abstract

The case of a 17-year-old male with isolated hypersecretion of dehydroepiandrosterone sulphate (DHEAS) is described. Cushing syndrome, congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency, an androgen producing adrenal tumour, and elevated plasma DHEAS due to an increased renal threshold were excluded. Selective renal vein catheterization confirmed bilateral, isolated adrenal DHEAS hypersecretion. The dexamethasone suppression suggests a functional nature of this alteration. This condition has to be considered in the differential diagnosis of excessive andrenal androgen production in males, or of hirsutism in females.

Key words

DHEAS Hirsutism Adrenal hyperfunction 

Abbreviations

ACTH

adrenocorticotropic hormone

DHEAS

dehydroepiandrosterone sulphate

17OHP

17OH-progesterone

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • G. Radetti
    • 1
  • E. Cacciari
    • 2
  • M. Zachmann
    • 3
  1. 1.Department of PaediatricsGeneral Hospital of BolzanoBolzanoItaly
  2. 2.Second Paediatric ClinicUniversity of BolognaItaly
  3. 3.Department of PaediatricsUniversity of ZürichSwitzerland

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