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European Journal of Pediatrics

, Volume 152, Issue 12, pp 998–1000 | Cite as

Effect of interleukin 2 on intractable herpes virus infection and chronic eczematoid dermatitis in a patient with Wiskott-Aldrich syndrome

  • H. Azuma
  • H. Sakata
  • M. Saijyou
  • A. Okuno
Immunology/Allergology

Abstract

Recombinant interleukin 2 (rIL2) was administered to a patient with Wiskott-Aldrich syndrome for the treatment of an intractabel facial herpetiforme lesion. This treatment appeared to be effective in suppressing the virus activity. At the same time, a transient improvement of the chronic eczematoid dermatitis was observed. During rIL2 administration, the CD3+ and CD4+ subsets of peripheral blood lymphocytes increased in number. These changes might play an important role in the induction of anti-viral immunity and in the improvement of dermatits.

Key words

Recombinant IL2 Wiskott-Aldrich syndrome Atopic dermatitis Herpes virus infection 

Abbreviations

rIL2

recombinant Interleukin 2

WAS

Wiskott-Aldrich syndrome

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References

  1. 1.
    Bich-Thuy LT, Dukovich M, Peter NJ, Fauci AS, Kehrl JH, Green WC (1987) Direct activation of human resting T cells by IL2: the role of an IL2 receptor distinct from the Tac protein. J Immunol 139:1550–1556PubMedGoogle Scholar
  2. 2.
    Chien CH, Hsieh K-H (1990) Interleukin-2 immunotherapy in children. Pediatr 86:937–943Google Scholar
  3. 3.
    Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang G-Y, Tarpey J, Damsky CH (1989) Adhessive and invasive interaction of human cytotrophoblast cells in vitro. J Cell Biol 109:891–902CrossRefPubMedGoogle Scholar
  4. 4.
    Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA (1982) Lymphokine-activated killer cell phenomenon: lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human preipheral blood lymphocytes. J Exp Med 155:1823–1841PubMedGoogle Scholar
  5. 5.
    Henney CS, Kuribayashi K, Kern DE, Gillis S (1981) Interleukin-2 augments natural killer cell activity. Nature 291:335–338CrossRefPubMedGoogle Scholar
  6. 6.
    Miyasaka N, Darnell B, Baron S, Talal N (1984) Interleukin-2 enhances natural killing of normal lymphocytes. Cell Immunol 84:154–162CrossRefPubMedGoogle Scholar
  7. 7.
    Ochs HD, Slichter SJ, Harker LA, Von Behrens WE, Clark RA, Wedgwiid RJ (1980) The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets. Blood 55:243–256PubMedGoogle Scholar
  8. 8.
    Pahwa R, Chatila T, Pahwa S, Paradise C, Day NK, Geha R, Schwartz SA, Slade H, Oyaizu N, Good RA (1989) Recombinant interleukin 2 therapy in severe combined immunodeficiency disease. Proc Natl Acad Sci 86:5069–5073PubMedGoogle Scholar
  9. 9.
    Rosenberg SA, Lotze MT, Muul LM, Chnag AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT, Seipp CA, Simpson CG, White DE (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokineactivated killer cells and interleukin-2 or high dose interleukin-2 alone. N Engl J Med 316:889–897PubMedGoogle Scholar
  10. 10.
    Rouse BT, Miller LS, Turtinen L, Moore RN (1985) Augmentation of immunity to herpes simplex virus by in vivo administration of interleukin2. J Immunol 134:926–930PubMedGoogle Scholar
  11. 11.
    Schmid DS (1988) The human MHC-restricted cellular response to herpes simplex virus type 1 is mediated by CD4+, CD8- T cells and is resticted to the DR region of the MHC complex. J Immunol 140:3610–3616PubMedGoogle Scholar
  12. 12.
    Sharon M, Siegel JP, Tosato G, Yodoi J, Gerrard TL, Leonard WJ (1988) The human interleukin 2 receptor chain (P70) Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells. J Exp Med 167:1265–1270CrossRefPubMedGoogle Scholar
  13. 13.
    Siegel JP, Sharon M, Smith PL, Leanard WJ (1987) The IL-2 receptor chain (P70): role in mediating signals for LAK, NK, and proliferative activities. Science 238:75–78PubMedGoogle Scholar
  14. 14.
    Torpey DJ, Lindsley MD, Rinald CR (1989) HLA-restricted lysis of herpes simplex virus-infected monocytes and macrophages mediated by CD4+ and CD8- T lymphocytes. J Immunol 142:1325–1332PubMedGoogle Scholar
  15. 15.
    Trinchieri G, Kobayashi MM, Clark SC, Seehra J, London L, Perussia B (1984) Response of resting human peripheral blood natural killer cells to interleukin 2. J Exp Med 160:1147–1169CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • H. Azuma
    • 1
  • H. Sakata
    • 1
  • M. Saijyou
    • 1
  • A. Okuno
    • 1
  1. 1.Department of PaediatricsAsahikawa Medical CollegeAsahikawa, Hokkaido 078Japan

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