European Journal of Pediatrics

, Volume 153, Issue 7, pp 538–539 | Cite as

Detection of increased urinary N-acetylaspartylglutamate in Canavan disease

  • A. P. Burlina
  • A. Corazza
  • V. Ferrari
  • P. Erhard
  • B. Künnecke
  • J. Seelig
  • A. B. Burlina
Leters to the Editors


Public Health Canavan Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.







  1. 1.
    Birken DL, Oldendorf WH (1989) N-acetyl-L-aspartic acid: a literatur review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 13:23–31PubMedGoogle Scholar
  2. 2.
    Blakely RD, Coyle JT (1988) The neurobiology of N-acetylaspartylglutamate. Int Rev Neurobiol 30:39–100PubMedGoogle Scholar
  3. 3.
    Cangro CB, Namboodiri MAA, Sklar LA, Corigliano-Murphy A, Neale JH (1987) Immunohistochemistry and biosynthesis of N-acetylaspartylglutamate in spinal sensory ganglia. J Neurochem 49:1579–1588PubMedGoogle Scholar
  4. 4.
    Matalon R, Kaul R, Michals K (1993) Canavan disease: biochemical and molecular studies. J Inherited Metab Dis 16:744–752CrossRefPubMedGoogle Scholar
  5. 5.
    Tieman SB, Butler K, Neale JH (1988) N-Acetylaspartylglutamate: a neuropeptide in the human visual system. JAMA 259:2020CrossRefPubMedGoogle Scholar
  6. 6.
    Tieman SB, Neale JH, Tieman DG (1991) N-Acetylaspartylglutamate immunoreactivity in neurons of the monkey's visual pathway. J Comp Neurol 313:45–64CrossRefPubMedGoogle Scholar
  7. 7.
    Tsai G, Stauch BL, Vornov JJ, Deshpande JK, Coyle JT (1990) Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo. Bram Res 518:313–316CrossRefGoogle Scholar
  8. 8.
    Zaczek R, Koller K, Cotter R, Heller D, Coyle JT (1983) N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain “glutamate” receptor. Proc Natl Acad Sci USA 80:1116–1119PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • A. P. Burlina
    • 1
  • A. Corazza
    • 2
  • V. Ferrari
    • 3
  • P. Erhard
    • 4
  • B. Künnecke
    • 4
  • J. Seelig
    • 4
  • A. B. Burlina
    • 5
  1. 1.Institute of NeurologyUniversity of PadovaPadovaItaly
  2. 2.Department of Biological ChemistryUniversity of PadovaPadovaItaly
  3. 3.Center for Biomedical ResearchCastelfranco VenetoItaly
  4. 4.Department of Biophysical ChemistryBiocentre of the UniversityBaselSwitzerland
  5. 5.Department of PaediatricsUniversity of PadovaPadovaItaly

Personalised recommendations