Abstract
In the presence of copper certain 2,2′-bipyridyls show antimycoplasmal activity, whereas copper itself causes a toxic effect. In this paper results are presented to elucidate the mechanism of copper uptake in the presence of 2,9-dimethyl-1,10-phenanthroline. The time course of copper and/or ligand uptake under the applied conditions is consistent with a carrier transport mechanism in which 2,9-dimethyl-1,10-phenanthroline operates as a carrier for copper ions. The influence of valinomycin on copper uptake indicates that the transmembrane potential is not the driving force in the carrier process.
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Gaisser, HD., Van Der Goot, H., Stouthamer, A.H. et al. Investigation into the mechanism of copper uptake by Mycoplasma gallisepticum in the prescence of 2,9-dimethyl-1,10-phenanthroline. Pharmaceutisch Weekblad Scientific Edition 9, 315–320 (1987). https://doi.org/10.1007/BF01956511
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DOI: https://doi.org/10.1007/BF01956511