Abstract
Phytoalexins, defensive compounds produced by plants against microbial infections, were purified fromSophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2′,4′-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25 μg/ml.
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References
Hamada, S., and Slade, H. D., Microbiol. Rev.44 (1980) 331.
Loesche, W. J., Microbiol. Rev.50 (1986) 353.
Mandel, I. D., J. clin Periodont.15 (1988) 488.
Walker, C. B., J. clin. Periodont.15 (1988) 499.
Marsh, P. D., Caries Res.27 (1993) 72.
Balandrin, M. F., Klocke, J. A., Wurtele, E. S., and Bollinger, W. H., Science228 (1985) 1154.
Heisey, R. M., and Gorham, B. K., Lett. appl. Microbiol.14 (1992) 136.
Dzink, J. L., and Socransky, S. S., Antimicrob. Ag. Chemother.27 (1985) 663.
Wu-Yuan, C. D., Chen, C. Y., and Wu, R. T., J. dent. Res.67 (1988) 51.
Sakanaka, S., Kim, M., Taniguchi, M., and Yamamoto, T., Agric. biol. Chem.53 (1989) 2307.
Osawa, K., Yasuda, H., Maruyama, T., Morita, H., Takeya, K., and Itokawa, H., Chem. pharm. Bull.40 (1992) 2970.
Dixon, R. A., Dey, P. M., and Lamb, C. J., Adv. Enzymol.55 (1983) 1.
Ebel, J., and Grisebach, H., Trends biochem. Sci.13 (1988) 23.
Ruangrungsi N., Iinuma, M., Tanaka, T., Ohyama, M., Yokoyama, J., and Mizuno, M., Phytochem.31 (1992) 999.
Sato, M., Tsuchiya, H., Akagiri, M., Fujiwara, S., Fujii, T., Takagi, N., Matsuura, N., and Iinuma, M., Lett. appl. Microbiol.18 (1994) 53.
Pathak, D., Pathak, K., and Singla, A. K., Fitoterapia62 (1991) 371.
Gjermo, P., J. dent. Res.68 (1989) 1602.
Harborne, J. B., in: Plant Flavonoids in Biology and Medicine II. Biochemical, Cellular, and Medicinal Properties, p. 17. Eds V. Cody, E. Middleton, Jr., J. B. Harborne and A. Beretz. Alan R. Liss, New York 1988.
Havsteen, B., Biochem. Pharmac.32 (1983) 1141.
Biswas, P., Bhattacharyya, A., Bose, P. C., Mukherjee, N., and Adityachaudhury, N., Experientia37 (1981) 397.
Cody, V., in: Plant Flavonoids in Biology and Medicine II. Biochemical, Cellular, and Medicinal Properties, p. 29. Eds V. Cody, E. Middleton, Jr., J. B. Harborne and A. Beretz. Alan R. Liss, New York 1988.
Hull, P. S., J. clin. Periodont.9 (1980) 431.
Scheie, A. A., J. dent. Res.68 (1989) 1609.
Marsh, P. D., J. clin. Periodont.18 (1991) 462.
Kubo, I., and Himejima, M., Experientia48 (1992) 1162.
Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., and Hara, Y., Chem. pharm. Bull.38 (1990) 717.
Otake, S., Makimura, M., Kuroki, T., Nishihara, Y., and Hirasawa, M., Caries Res.25 (1991) 438.
Jones, C. L., Ritchie, J. A., Marsh, P. D., and van der Ouderaa, F., J. dent. Res.67 (1988) 46.
Minah, G. E., DePaola, L. G., Overholser, C. D., Meiller, T. F., Niehaus, C., Lamm, R. A., Ross, N. M., and Dills, S. S., J. clin. Periodont.16 (1989) 347.
Southard, G. L., Boulware, R. T., Walborn, D. R., Groznik, W. J., Thorne, E. M., and Yankell, S. L., J. Am. dent. Assoc.108 (1984) 338.
Harkrader, R. J., Reinhart, P. C., Rogers, J. A., Jones, R. R., Wylie, II, R. E., Lowe, B. K., and McEvoy, R. M., J. Can. dent. Assoc.56 Suppl. (1990) 7.
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Tsuchiya, H., Sato, M., Iinuma, M. et al. Inhibition of the growth of cariogenic bacteria in vitro by plant falvanones. Experientia 50, 846–849 (1994). https://doi.org/10.1007/BF01956469
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DOI: https://doi.org/10.1007/BF01956469