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Inhibition of the growth of cariogenic bacteria in vitro by plant falvanones

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Abstract

Phytoalexins, defensive compounds produced by plants against microbial infections, were purified fromSophora exigua (Leguminosae) and their growth inhibitory effects on oral cariogenic bacteria were determined in vitro. Among three isolated compounds, 5,7,2′,4′-tetrahydroxy-8-lavandulylflavanone completely inhibited the growth of oral bacteria including primary cariogenic mutans streptococci, other oral streptococci, actinomycetes, and lactobacilli, at concentrations of 1.56 to 6.25 μg/ml.

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References

  1. Hamada, S., and Slade, H. D., Microbiol. Rev.44 (1980) 331.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Loesche, W. J., Microbiol. Rev.50 (1986) 353.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Mandel, I. D., J. clin Periodont.15 (1988) 488.

    Article  CAS  Google Scholar 

  4. Walker, C. B., J. clin. Periodont.15 (1988) 499.

    Article  CAS  Google Scholar 

  5. Marsh, P. D., Caries Res.27 (1993) 72.

    Article  PubMed  Google Scholar 

  6. Balandrin, M. F., Klocke, J. A., Wurtele, E. S., and Bollinger, W. H., Science228 (1985) 1154.

    Article  CAS  PubMed  Google Scholar 

  7. Heisey, R. M., and Gorham, B. K., Lett. appl. Microbiol.14 (1992) 136.

    Article  Google Scholar 

  8. Dzink, J. L., and Socransky, S. S., Antimicrob. Ag. Chemother.27 (1985) 663.

    Article  CAS  Google Scholar 

  9. Wu-Yuan, C. D., Chen, C. Y., and Wu, R. T., J. dent. Res.67 (1988) 51.

    Article  CAS  PubMed  Google Scholar 

  10. Sakanaka, S., Kim, M., Taniguchi, M., and Yamamoto, T., Agric. biol. Chem.53 (1989) 2307.

    CAS  Google Scholar 

  11. Osawa, K., Yasuda, H., Maruyama, T., Morita, H., Takeya, K., and Itokawa, H., Chem. pharm. Bull.40 (1992) 2970.

    Article  CAS  Google Scholar 

  12. Dixon, R. A., Dey, P. M., and Lamb, C. J., Adv. Enzymol.55 (1983) 1.

    CAS  PubMed  Google Scholar 

  13. Ebel, J., and Grisebach, H., Trends biochem. Sci.13 (1988) 23.

    Article  CAS  PubMed  Google Scholar 

  14. Ruangrungsi N., Iinuma, M., Tanaka, T., Ohyama, M., Yokoyama, J., and Mizuno, M., Phytochem.31 (1992) 999.

    Article  CAS  Google Scholar 

  15. Sato, M., Tsuchiya, H., Akagiri, M., Fujiwara, S., Fujii, T., Takagi, N., Matsuura, N., and Iinuma, M., Lett. appl. Microbiol.18 (1994) 53.

    Article  CAS  Google Scholar 

  16. Pathak, D., Pathak, K., and Singla, A. K., Fitoterapia62 (1991) 371.

    CAS  Google Scholar 

  17. Gjermo, P., J. dent. Res.68 (1989) 1602.

    CAS  Google Scholar 

  18. Harborne, J. B., in: Plant Flavonoids in Biology and Medicine II. Biochemical, Cellular, and Medicinal Properties, p. 17. Eds V. Cody, E. Middleton, Jr., J. B. Harborne and A. Beretz. Alan R. Liss, New York 1988.

    Google Scholar 

  19. Havsteen, B., Biochem. Pharmac.32 (1983) 1141.

    Article  CAS  Google Scholar 

  20. Biswas, P., Bhattacharyya, A., Bose, P. C., Mukherjee, N., and Adityachaudhury, N., Experientia37 (1981) 397.

    Article  CAS  Google Scholar 

  21. Cody, V., in: Plant Flavonoids in Biology and Medicine II. Biochemical, Cellular, and Medicinal Properties, p. 29. Eds V. Cody, E. Middleton, Jr., J. B. Harborne and A. Beretz. Alan R. Liss, New York 1988.

    Google Scholar 

  22. Hull, P. S., J. clin. Periodont.9 (1980) 431.

    Article  Google Scholar 

  23. Scheie, A. A., J. dent. Res.68 (1989) 1609.

    CAS  Google Scholar 

  24. Marsh, P. D., J. clin. Periodont.18 (1991) 462.

    Article  CAS  Google Scholar 

  25. Kubo, I., and Himejima, M., Experientia48 (1992) 1162.

    Article  CAS  PubMed  Google Scholar 

  26. Hattori, M., Kusumoto, I. T., Namba, T., Ishigami, T., and Hara, Y., Chem. pharm. Bull.38 (1990) 717.

    Article  CAS  Google Scholar 

  27. Otake, S., Makimura, M., Kuroki, T., Nishihara, Y., and Hirasawa, M., Caries Res.25 (1991) 438.

    Article  CAS  PubMed  Google Scholar 

  28. Jones, C. L., Ritchie, J. A., Marsh, P. D., and van der Ouderaa, F., J. dent. Res.67 (1988) 46.

    Article  CAS  PubMed  Google Scholar 

  29. Minah, G. E., DePaola, L. G., Overholser, C. D., Meiller, T. F., Niehaus, C., Lamm, R. A., Ross, N. M., and Dills, S. S., J. clin. Periodont.16 (1989) 347.

    Article  CAS  Google Scholar 

  30. Southard, G. L., Boulware, R. T., Walborn, D. R., Groznik, W. J., Thorne, E. M., and Yankell, S. L., J. Am. dent. Assoc.108 (1984) 338.

    Article  CAS  PubMed  Google Scholar 

  31. Harkrader, R. J., Reinhart, P. C., Rogers, J. A., Jones, R. R., Wylie, II, R. E., Lowe, B. K., and McEvoy, R. M., J. Can. dent. Assoc.56 Suppl. (1990) 7.

    CAS  PubMed  Google Scholar 

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Tsuchiya, H., Sato, M., Iinuma, M. et al. Inhibition of the growth of cariogenic bacteria in vitro by plant falvanones. Experientia 50, 846–849 (1994). https://doi.org/10.1007/BF01956469

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