European Journal of Pediatrics

, Volume 150, Issue 5, pp 310–313 | Cite as

Abnormal results of biochemical liver function tests in breast-fed infants with prolonged indirect hyperbilirubinaemia

  • Y. Tazawa
  • D. Abukawa
  • M. Watabe
  • M. Nakagawa
  • M. Yamada
Gastroenterology/Hepatology

Abstract

To clarify the relationship between hyperbilirubinaemia and abnormal results of biochemical liver function tests in infants with breast milk jaundice (BMJ), 58 breast-fed infants with indirect hyperbilirubinaemia were enrolled in this study. Sera obtained from the above infants were subjected to routine liver function tests. Although serum transaminases were within normal limits in all 58 patients, serum alkaline phosphatase levels were abnormally increased in 13, gamma-glutamyltranspeptidase in 8 and total bile acids in 11 out of all patients examined. A total of 18 (31%) patients had abnormal results in at least one item of the liver function tests. The intrinsic bile acid loading test showed postprandial increases in bile acids in 5 of 16 (31%) patients examined at either 60 or 120 min, while all 13 breast-fed, agematched controls had no abnormal results. The decrease in rate of serum bilirubin levels after the 3-day discontinuation of breast-feeding was significantly less in patients with increased fasting bile acids than in patients with normal fasting levels of serum bile acids. These results may suggest that mild hepatic dysfunction or cholestasis is associated with indirect hyperbilirubinaemia in some infants with BMJ.

Key words

Breast milk jaundice Liver dysfunction Cholestasis 

Abbreviations

ALP

alkaline phosphatase

BMJ

breast milk jaundice

GGTP

gamma-glutamyltranspeptidase

GOT

glutamic oxalacetic transaminase

GPT

glutamic pyruvic transaminase

TBA

total bile acids

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Y. Tazawa
    • 1
  • D. Abukawa
    • 2
  • M. Watabe
    • 2
  • M. Nakagawa
    • 2
  • M. Yamada
    • 3
  1. 1.Department of PaediatricsAkita University School of MedicineAkitaJapan
  2. 2.Department of PaediatricsTohoku University School of MedicineSendaiJapan
  3. 3.Department of Neonatal Intensive Care UnitSendai Red Cross HospitalSendaiJapan

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