Experientia

, Volume 38, Issue 12, pp 1487–1489 | Cite as

Dystrophic mutation (dy2J) affecting regulation of lactate dehydrogenase (LDH) and pyruvate kinase (PK) in C57BL/6J mice

  • Shiva M. Singh
  • Caroline H. Wang
  • Ann Phillips
Short Communications Genetics, Developmental Biology, Aging
  • 15 Downloads

Summary

The genotype difference (dystrophic vs nondystrophic) in the LDH isozymes is observed in kidney. These differences are evident only at birth and at early developmental stages (before the expression of dystrophic symptoms). The tissue specific genotype differences for PK are limited to the thigh muscle (M form) and heart (L form), after the onset of the condition. These differences may reflect the pleiotropic effect of the dy2J locus during the temporal regulation of these and other enzymes implicated in muscular dystrophy (MD).

Keywords

Enzyme Lactate Pyruvate Developmental Stage Temporal Regulation 

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • Shiva M. Singh
    • 1
  • Caroline H. Wang
    • 1
  • Ann Phillips
    • 1
  1. 1.Department of ZoologyUniversity of Western OntarioLondonCanada

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